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| Titre : |
Effects of varenicline on smoking cessation in mild-to moderate COPD : a randomized controlled trial |
| Type de document : |
texte imprimé |
| Auteurs : |
D.P. Tashkin, Auteur ; Stephen I Rennard, Auteur ; J. Taylor Hays, Auteur |
| Editeur : |
American College of Chest Physicians |
| Année de publication : |
2010 |
| Collection : |
Chest, ISSN 0012-3692 |
| Importance : |
30 p. |
| Présentation : |
tab. |
| Langues : |
Français (fre) |
| Catégories : |
[TABAC] étude
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:varénicline
|
| Index. décimale : |
TA 6.2.3.1.4 Autres substituts nicotiniques |
| Résumé : |
BACKGROUND:
Smoking is the most important risk factor for COPD and accelerates its progression. Despite the health implications, a large proportion of patients with COPD continue to smoke, so finding effective smoking cessation interventions for this population is paramount. To our knowledge, this is the first randomized clinical trial to compare the efficacy and safety of varenicline tartrate vs placebo in smokers with mild to moderate COPD.
METHODS:
In a 27-center, double-blind, multinational study, 504 patients with mild to moderate COPD (postbronchodilator FEV1/FVC,
RESULTS:
CAR for weeks 9 to 12 was significantly higher for patients in the varenicline group (42.3%) than for those in the placebo group (8.8%) (OR, 8.40; 95% CI, 4.99-14.14; P<.0001 car in the patients treated with varenicline remained significantly higher than those placebo through weeks to vs ci p nausea abnormal dreams upper-respiratory tract infection and insomnia were most commonly reported adverse events for group. serious aes infrequent both treatment groups. two group one patient died during study. reports of psychiatric similar>
CONCLUSIONS:
Varenicline was more efficacious than placebo for smoking cessation in patients with mild to moderate COPD and demonstrated a safety profile consistent with that observed in previous trials. |
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