| Titre : |
A comparison of sustained-release bupropion and placebo for smoking cessation |
| Type de document : |
texte imprimé |
| Auteurs : |
Richard D. Hurt, Auteur ; David P.L. Sachs, Auteur ; Elbert T. Glover, Auteur ; Kenneth P. Offord, Auteur |
| Editeur : |
Massachusetts Medical Society |
| Année de publication : |
1997 |
| Collection : |
New England Journal of Medicine num. 337:17 |
| Importance : |
p. 1195-1202 |
| Présentation : |
tab., graph. |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] étude
[TABAC] étude:recherche:recherche clinique:essai clinique randomisé
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:bupropion
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:placebo
|
| Index. décimale : |
TA 6.2.3.2 Autres produits |
| Résumé : |
BACKGROUND AND METHODS:
Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double-blind, placebo-controlled trial of a sustained-release form of bupropion for smoking cessation. We excluded smokers with current depression, but not those with a history of major depression. The 615 subjects were randomly assigned to receive placebo or bupropion at a dose of 100, 150, or 300 mg per day for seven weeks. The target quitting date (or "target quit date") was one week after the beginning of treatment. Brief counseling was provided at base line, weekly during treatment, and at 8, 12, 26, and 52 weeks. Self-reported abstinence was confirmed by a carbon monoxide concentration in expired air of 10 ppm or less.
RESULTS:
At the end of seven weeks of treatment, the rates of smoking cessation as confirmed by carbon monoxide measurements were 19.0 percent in the placebo group, 28.8 percent in the 100-mg group, 38.6 percent in the 150-mg group, and 44.2 percent in the 300-mg group (P
CONCLUSIONS:
A sustained-release form of bupropion was effective for smoking cessation and was accompanied by reduced weight gain and minimal side effects. Many participants in all groups were smoking at one year. |
| En ligne : |
https://www.nejm.org/doi/10.1056/NEJM199710233371703?url_ver=Z39.88-2003&rfr_id= [...] |
| Format de la ressource électronique : |
HTML |
| Permalink : |
http://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8138 |
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