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| Titre : |
Have combustible cigarettes met their match : The nicotine delivery profiles and harmful constituent exposures of second-generation and third-generation electronic cigarette users |
| Type de document : |
document électronique |
| Auteurs : |
Theodore L. Wagener, Auteur ; Evan L. Floyd, Auteur ; Irina Stepanov, Auteur ; Leslie M. Driskill, Auteur ; Summer G. Frank, Auteur ; Ellen Meier, Auteur ; Eleanor L. Leavens, Auteur ; Alayna P. Tackett, Auteur ; Neil Molina, Auteur ; Lurdes Queimado, Auteur |
| Editeur : |
BMJ Publishing Group |
| Année de publication : |
2016 |
| Collection : |
Tobacco Control |
| Importance : |
6 p. |
| Présentation : |
tab. ; graph. |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] prévention:stratégie:réduction du risque
[TABAC] tabagisme:effet du tabac:toxicité
[TABAC] tabagisme:pathologie:cancer
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| Index. décimale : |
TA 5.8 Réduction des risques |
| Résumé : |
Introduction: Electronic cigarettes' (e-cigarettes) viability as a public health strategy to end smoking will likely be determined by their ability to mimic the pharmacokinetic profile of a cigarette while also exposing users to significantly lower levels of harmful/potentially harmful constituents (HPHCs). The present study examined the nicotine delivery profile of third- (G3) versus second-generation (G2) e-cigarette devices and their users' exposure to nicotine and select HPHCs compared with cigarette smokers.
Methods: 30 participants (10 smokers, 9 G2 and 11 G3 users) completed baseline questionnaires and provided exhaled carbon monoxide (eCO), saliva and urine samples. Following a 12-hour nicotine abstinence, G2 and G3 users completed a 2-hour vaping session (ie, 5 min, 10-puff bout followed by ad libitum puffing for 115 min). Blood samples, subjective effects, device characteristics and e-liquid consumption were assessed.
Results: Smokers, G2 and G3 users had similar baseline levels of cotinine, but smokers had 4 and 7 times higher levels of eCO (p
Discussion: Under normal use conditions, both G2 and G3 devices deliver cigarette-like amounts of nicotine, but G3 devices matched the amount and speed of nicotine delivery of a conventional cigarette. Compared with cigarettes, G2 and G3 e-cigarettes resulted in significantly lower levels of exposure to a potent lung carcinogen and cardiovascular toxicant. These findings have significant implications for understanding the addiction potential of these devices and their viability/suitability as aids to smoking cessation.
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| En ligne : |
https://doi.org/10.1136/tobaccocontrol-2016-053041 |
| Format de la ressource électronique : |
Article en ligne |
| Permalink : |
http://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9620 |
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