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A comparison of sustained-release bupropion and placebo for smoking cessation / Richard D. Hurt (1997)
Titre : A comparison of sustained-release bupropion and placebo for smoking cessation Type de document : texte imprimé Auteurs : Richard D. Hurt, Auteur ; David P.L. Sachs, Auteur ; Elbert T. Glover, Auteur ; Kenneth P. Offord, Auteur Editeur : Massachusetts Medical Society Année de publication : 1997 Collection : New England Journal of Medicine num. 337:17 Importance : p. 1195-1202 Présentation : tab., graph. Langues : Anglais (eng) Catégories : [TABAC] étude
[TABAC] étude:recherche:recherche clinique:essai clinique randomisé
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:bupropion
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:placeboIndex. décimale : TA 6.2.3.2 Autres produits Résumé : BACKGROUND AND METHODS:
Trials of antidepressant medications for smoking cessation have had mixed results. We conducted a double-blind, placebo-controlled trial of a sustained-release form of bupropion for smoking cessation. We excluded smokers with current depression, but not those with a history of major depression. The 615 subjects were randomly assigned to receive placebo or bupropion at a dose of 100, 150, or 300 mg per day for seven weeks. The target quitting date (or "target quit date") was one week after the beginning of treatment. Brief counseling was provided at base line, weekly during treatment, and at 8, 12, 26, and 52 weeks. Self-reported abstinence was confirmed by a carbon monoxide concentration in expired air of 10 ppm or less.
RESULTS:
At the end of seven weeks of treatment, the rates of smoking cessation as confirmed by carbon monoxide measurements were 19.0 percent in the placebo group, 28.8 percent in the 100-mg group, 38.6 percent in the 150-mg group, and 44.2 percent in the 300-mg group (P<0.001). At one year the respective rates were 12.4 percent, 19.6 percent, 22.9 percent, and 23.1 percent. The rates for the 150-mg group (P=0.02) and the 300-mg group (P=0.01) -- but not the 100-mg group (P=0.09) -- were significantly better than those for the placebo group. Among the subjects who were continuously abstinent through the end of treatment, the mean absolute weight gain was inversely associated with the dose (a gain of 2.9 kg in the placebo group, 2.3 kg in 100-mg and 150-mg groups, and 1.5 kg in the 300-mg group; P= 0.02). No effects of treatment were observed on depression scores as measured serially by the Beck Depression Inventory. Thirty-seven subjects stopped treatment prematurely because of adverse events; the frequency was similar among all groups.
CONCLUSIONS:
A sustained-release form of bupropion was effective for smoking cessation and was accompanied by reduced weight gain and minimal side effects. Many participants in all groups were smoking at one year.En ligne : https://www.nejm.org/doi/10.1056/NEJM199710233371703?url_ver=Z39.88-2003&rfr_id= [...] Format de la ressource électronique : HTML Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8138 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Efficacy of varenicline, an alpha-4-beta-2 nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation / Douglas E. Jorenby (01/06/2006)
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Code-barres Cote Support Localisation Section Disponibilité TA 001432 TA 6.2.3.1.4 JOR E Article/Périodique Bibliothèque FARES Tabac Consultation sur place
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Varenicline, an alpha-4-beta-2(α4β2) nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation / David H. Gonzales (01/06/2006)
Titre : Varenicline, an alpha-4-beta-2(α4β2) nicotinic acetylcholine receptor partial agonist, vs placebo or sustained-release bupropion for smoking cessation : a randomized controlled trial Type de document : texte imprimé Auteurs : David H. Gonzales, Auteur ; Stephen I Rennard, Auteur ; Mitchell Nides, Auteur Editeur : American Medical Association (AMA) Année de publication : 01/06/2006 Collection : JAMA : Journal of the American Medical Association num. 296 (1) Importance : p.47-55 Langues : Anglais (eng) Catégories : [TABAC] étude
[TABAC] étude:recherche:recherche clinique:essai clinique randomisé
[TABAC] sevrage tabagique
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:bupropion
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:placebo
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:varéniclineIndex. décimale : TA 6.2.3.1.4 Autres substituts nicotiniques En ligne : https://jamanetwork.com/journals/jama/fullarticle/211000 Format de la ressource électronique : HTML Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=2587 Aucun avis, veuillez vous identifier pour ajouter le vôtre !