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Titre : Mefloquine as a potential drug against multidrug-resistant tuberculosis Type de document : document électronique Auteurs : David Krieger, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2015 Collection : European Respiratory Journal num. Vol 58 Issue 4 Importance : 3 p. Présentation : tab. Langues : Anglais (eng) Catégories : [TUBER] traitement
[TUBER] traitement:résistance:multirésistanceIndex. décimale : TU 3.2. MDR (Multi Drug Resistance) / XDR (X-treme Drug Resistance) En ligne : https://www.doi.org/10.1183/13993003.00321-2015 Format de la ressource électronique : Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9414 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Monitoring latent tuberculosis infection diagnosis and management in the Netherlands / C.G.M. Erkens (2016)
Titre : Monitoring latent tuberculosis infection diagnosis and management in the Netherlands Type de document : document électronique Auteurs : C.G.M. Erkens, Auteur ; E. Slump, Auteur ; Maurits Verhagen, Auteur ; H.J. Schimmel, Auteur ; Gerard de Vries, Auteur ; Frank Cobelens, Auteur ; Susan van den Hof, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2016 Collection : European Respiratory Journal num. vol.47 nr 4 Importance : p.1492-1501 Langues : Anglais (eng) Catégories : [DIVERS] géographie:Europe:Europe occidentale:Pays-Bas
[TUBER] diagnostic
[TUBER] traitement
[TUBER] type de tuberculose:infection tuberculeuse latenteIndex. décimale : TU 2. Type de tuberculose et pathogies similaires Résumé : Targeted diagnosis and treatment of latent tuberculosis (TB) infection (LTBI) among persons with a high risk of exposure to TB or of developing TB when infected has been performed and monitored routinely in the Netherlands since 1993. We describe trends in target groups, diagnostic methods and treatment regimens, and explore determinants for treatment initiation, treatment completion and adverse events.
In total, 37 729 persons were registered with LTBI from 1993 to 2013, of whom 28 931 (77%) started preventive treatment; 82% of those completed preventive treatment and 8% stopped preventive treatment due to adverse events. Two-thirds of the notified cases were detected through contact investigation.
Increasing numbers of persons with immunosuppressive disorders, elderly persons and foreign-born persons were notified in recent years, due to policy changes and the introduction of the interferon-γ release assay. Children (96%) and the immunosuppressed (95%) were more likely to start preventive treatment. Children (93%) were also more likely to complete preventive treatment, as were persons treated with rifampicin or rifampicin/isoniazid regimens (91% and 92%, respectively). The latter groups were also 40% less likely to stop preventive treatment due to adverse events.
Under these operational conditions, the estimated risk reduction on incident TB in the target population for LTBI management is 40–60%.En ligne : https://doi.org/10.1183/13993003.01397-2015 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10153 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by humain airway smooth muscle cells / R. Gosens (2009)
Titre : Muscarinic M3 receptor stimulation increases cigarette smoke-induced IL-8 secretion by humain airway smooth muscle cells Type de document : texte imprimé Auteurs : R. Gosens, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2009 Collection : European Respiratory Journal num. 34 (6) Importance : p.1436-1443 Langues : Anglais (eng) Catégories : [TABAC] tabagisme:effet du tabac
[TABAC] tabagisme:tabagisme actifIndex. décimale : TA 3.2.2.6 Effets métaboliques et biologiques Résumé : Acetylcholine is the primary parasympathetic neurotransmitter in the airways and is known to cause bronchoconstriction and mucus secretion. Recent findings suggest that acetylcholine also regulates aspects of remodelling and inflammation through its action on muscarinic receptors. In the present study, we aimed to determine the effects of muscarinic receptor stimulation on cytokine production by human airway smooth muscle cells (primary and immortalised cell lines). The muscarinic receptor agonists carbachol and methacholine both induced modest effects on basal interleukin (IL)-8 and -6 secretion, whereas the secretion of RANTES, eotaxin, vascular endothelial growth factor-A and monocyte chemoattractant protein-1 was not affected. Secretion of IL-8 and -6 was only observed in immortalised airway smooth muscle cells that express muscarinic M3 receptors. In these cells, methacholine also significantly augmented IL-8 secretion in combination with cigarette smoke extract in a synergistic manner, whereas synergistic effects on IL-6 secretion were not significant. Muscarinic M3 receptors were the primary subtype involved in augmenting cigarette smoke extract-induced IL-8 secretion, as only tiotropium bromide and muscarinic M3 receptor subtype selective antagonists abrogated the effects of methacholine. Collectively, these results indicate that muscarinic M3 receptor stimulation augments cigarette smoke extract-induced cytokine production by airway smooth muscle. This interaction could be of importance in patients with chronic obstructive pulmonary disease. En ligne : https://erj.ersjournals.com/content/34/6/1436 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=2705 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
No added value of interferon-γ release to a prediction model for childhood tuberculosis / Toyin O. Togun (2016)
Titre : No added value of interferon-γ release to a prediction model for childhood tuberculosis Type de document : document électronique Auteurs : Toyin O. Togun, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2016 Collection : European Respiratory Journal num. 47 Importance : p.223-232 Langues : Anglais (eng) Catégories : [DIVERS] personne:famille:enfant
[TUBER] diagnostic:test immunologique:test IGRAIndex. décimale : TU 3.4. Enfant En ligne : https://doi.org/10.1183/13993003.00890-2015 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9423 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Old ideas to innovate tuberculosis control : preventive treatment to achieve elimination Type de document : document électronique Auteurs : Roland Diel, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2013 Collection : European Respiratory Journal num. 42 Importance : p.785-801 Langues : Anglais (eng) Catégories : [TUBER] prévention:stratégie Index. décimale : TU 3.1. Généralités En ligne : https://doi.org/10.1183/09031936.00205512 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9387 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Perinatal air pollution exposure and development of asthma from birth to age 10 years / Hind Sbihi (2016)
Titre : Perinatal air pollution exposure and development of asthma from birth to age 10 years Type de document : document électronique Auteurs : Hind Sbihi, Auteur ; Lillian Tamburic, Auteur ; Mieke Koehoorn, Auteur ; Michael Brauer, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2016 Collection : European Respiratory Journal num. 47(4) Importance : p.1062-1071 Langues : Anglais (eng) Catégories : [DIVERS] personne:famille:enfant
[PROMOSAN] allergie:cause d'allergie:facteur aggravant:pollution
[PROMOSAN] asthme
[TABAC] tabagisme:effet sur l'environnement:pollution
[TABAC] tabagisme:pathologie:pathologie respiratoire:asthmeIndex. décimale : AA 1.6. Asthme chez l'enfant En ligne : https://doi.org/10.1183/13993003.00746-2015 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9431 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Pharmacokinetics of ertapenem in patients with multidrug-resistant tuberculosis / Sander P. van Rijn (2016)
Titre : Pharmacokinetics of ertapenem in patients with multidrug-resistant tuberculosis Type de document : document électronique Auteurs : Sander P. van Rijn, Auteur ; Richard van Altena, Auteur ; Onno W. Akkerman, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2016 Collection : European Respiratory Journal num. vol.47 nr 4 Importance : p. 1229-1234 Présentation : graph. Langues : Anglais (eng) Catégories : [TUBER] étude
[TUBER] traitement:résistanceIndex. décimale : TU 8.5.1. MDR (Multi Drug Resistance / XDR (X-treme Drug Resistance) Résumé : Treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) is becoming more challenging because of increased levels of drug resistance against second-line TB drugs. One promising group of antimicrobial drugs is carbapenems. Ertapenem is an attractive carbapenem for the treatment of MDR- and XDR-TB because its relatively long half-life enables once-daily dosing.
A retrospective study was performed for all patients with suspected MDR-TB at the Tuberculosis Center Beatrixoord of the University Medical Center Groningen (Haren, the Netherlands) who received ertapenem as part of their treatment regimen between December 1, 2010 and March 1, 2013. Safety and pharmacokinetics were evaluated.
18 patients were treated with 1000 mg ertapenem for a mean (range) of 77 (5–210) days. Sputum smear and culture were converted in all patients. Drug exposure was evaluated in 12 patients. The mean (range) area under the concentration–time curve up to 24 h was 544.9 (309–1130) h·mg·L−1. The mean (range) maximum observed plasma concentration was 127.5 (73.9–277.9) mg·L−1.
In general, ertapenem treatment was well tolerated during MDR-TB treatment and showed a favourable pharmacokinetic/pharmacodynamic profile in MDR-TB patients. We conclude that ertapenem is a highly promising drug for the treatment of MDR-TB that warrants further investigation.En ligne : https://www.doi.org/10.1183/13993003.01654-2015 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10149 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2 / G. De Cunto (2011)
Titre : Pulmonary hypertension in smoking mice over-expressing protease-activated receptor-2 Type de document : texte imprimé Auteurs : G. De Cunto, Auteur ; S. Cardini, Auteur ; G. Cirino, Auteur ; G. Lungarella, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2011 Collection : European Respiratory Journal num. 37 Importance : p.823-834 Présentation : tab., graph., ill. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:fumée
[TABAC] étudeIndex. décimale : TA 3.2.2.1 Expérimentation Résumé : The mechanism(s) involved in the development of pulmonary hypertension (PH) in COPD is still the object of investigation. Cigarette smoke (CS) may lead to remodelling of intrapulmonary vessels and dynamic changes in vascular function, at least in some smokers. A role for proteases in PH has been recently put forward. We investigated, in smoking mice, the role of protease-activated receptor (PAR)-2 in the pathogenesis of PH associated with emphysema. We demonstrated that CS exposure can modulate PAR-2 expression in mouse lung. Acute CS exposure induces in wildtype (WT) and in transgenic mice over-expressing PAR-2 (FVB(PAR-2-TgN)) a similar degree of neutrophil influx in bronchoalveolar lavage fluids. After chronic CS exposure WT and FVB(PAR-2-TgN) mice show emphysema, but only transgenic mice develop muscularisation of small intrapulmonary vessels that precedes the development of PH (~45% increase) and right ventricular hypertrophy. Smoking in FVB(PAR-2-TgN) mice results in an imbalance between vasoconstrictors (especially endothelin-1) and vasodilators (i.e. vascular endothelial growth factor, endothelial nitric oxide synthase and inducible nitric oxide synthase) and enhanced production of growth factors involved both in fibroblast-smooth muscle cell transaction (i.e. platelet-derived growth factor (PDGF) and transforming growth factor β) and vascular cell proliferation (PDGF). PAR-2 signalling can influence the production and release of many factors, which may play a role in the development of PH in smokers.
PMID: 20693251 DOI: 10.1183/09031936.00060210En ligne : https://erj.ersjournals.com/content/37/4/823.long Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8072 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Risk factors for the misdiagnosis of tuberculosis in the UK, 2001-2011 Type de document : document électronique Auteurs : Deborah Pedrazzoli, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2015 Collection : European Respiratory Journal num. 46 Importance : p.564-567 Présentation : tab. Langues : Anglais (eng) Catégories : [DIVERS] géographie:Europe:Europe occidentale:Royaume-Uni
[TUBER] diagnostic
[TUBER] type de tuberculose:tuberculose-maladieIndex. décimale : TU 5. Méthodes de diagnostic En ligne : www.doi.org/10.1183/09031936.00227914 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9403 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Sensitivity of C-Tb: a novel RD-1-specific skin test for the diagnosis of tuberculosis infection / Soren T. Hoff (2016)
Titre : Sensitivity of C-Tb: a novel RD-1-specific skin test for the diagnosis of tuberculosis infection Type de document : document électronique Auteurs : Soren T. Hoff, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2016 Collection : European Respiratory Journal num. 47 Importance : p.919-928 Langues : Anglais (eng) Catégories : [TUBER] diagnostic
[TUBER] type de tuberculose:tuberculose-maladieIndex. décimale : TU 5. Méthodes de diagnostic En ligne : https://doi.org/10.1183/13993003.01464-2015 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9433 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Short-course treatment for multidrugresistant tuberculosis: the STREAM trials Type de document : document électronique Auteurs : Riya Moodley, Auteur ; Thomas R. Godec, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2016 Collection : European Respiratory Journal num. 25 Importance : p.29-35 Langues : Anglais (eng) Catégories : [TUBER] traitement:résistance:multirésistance
[TUBER] traitement:traitement curatifIndex. décimale : TU 8.5.1. MDR (Multi Drug Resistance / XDR (X-treme Drug Resistance) En ligne : https://doi.org/10.1183/16000617.0080-2015 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9437 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Smoking cessation interventions in COPD a network meta-analysis of randomised trials / R. Strassmann (2009)
Titre : Smoking cessation interventions in COPD a network meta-analysis of randomised trials : a network meta-analysis of randomised trials Type de document : texte imprimé Auteurs : R. Strassmann, Auteur ; B. Bausch, Auteur ; J. Kleijnen, Auteur ; O. Braendli, Auteur ; A. Spaar, Auteur ; M.A. Puhan, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2009 Collection : European Respiratory Journal num. 34 Importance : p. 634-640 Présentation : tab. Langues : Anglais (eng) Catégories : [TABAC] étude
[TABAC] sevrage tabagique:aide au sevrage:conseil de sevrage
[TABAC] sevrage tabagique:efficacité du sevrage
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:substitution nicotinique
[TABAC] tabagisme:pathologie:pathologie respiratoire:broncho-pneumopathie chronique obstructiveIndex. décimale : TA 6.2 Méthodes individuelles Résumé : The aim of this study was to rank order the effectiveness of smoking cessation interventions for chronic obstructive pulmonary disease (COPD) patients. We searched 10 databases to identify randomised trials of smoking cessation counselling (SCC) with or without pharmacotherapy or nicotine replacement therapy (NRT). We conducted a network meta-analysis using logistic regression analyses to assess the comparative effectiveness of smoking cessation interventions while preserving randomisation of each trial. The analysis of 7,372 COPD patients from six out of eight identified trials showed that SCC in combination with NRT had the greatest effect on prolonged abstinence rates versus usual care (OR 5.08, p<0.0001) versus SCC alone (2.80, p = 0.001) and versus SCC combined with an antidepressant (1.53, p = 0.28). The second most effective intervention was SCC combined with an antidepressant (3.32, p = 0.002) versus SCC alone (1.83, p = 0.007), with no difference between antidepressants. SCC alone was of borderline superiority compared with usual care (1.81, p = 0.07). A small body of evidence suggests that SCC combined with NRT is more effective than other combinations and single smoking cessation treatments in COPD, but substantially more research is needed for this most important COPD treatment. En ligne : https://erj.ersjournals.com/content/34/3/634 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8078 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Smoking resumption after lung transplantation : a sobering truth Type de document : texte imprimé Auteurs : R. Vos, Auteur ; K. De Vusser, Auteur ; R. Schoonis, Auteur ; Valentine Lemaigre, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2010 Collection : European Respiratory Journal num. 35:6 Importance : p.1411- 1413 Présentation : tab., ill. Langues : Anglais (eng) Catégories : [TABAC] étude
[TABAC] tabagisme:habitude tabagique
[TABAC] tabagisme:risque:facteur associé:chirurgieIndex. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) En ligne : https://erj.ersjournals.com/content/35/6/1411 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8089 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia / I.A.J. Giebelen (2009)
Titre : Stimulation of acetylcholine receptors impairs host defence during pneumococcal pneumonia Type de document : texte imprimé Auteurs : I.A.J. Giebelen, Auteur ; M. Leendertse, Auteur ; S. Florquin, Auteur ; T. van der Poll, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2009 Collection : European Respiratory Journal num. 33:2 Importance : p. 375-381 Présentation : tab., graph., ill Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] tabagisme:effet du tabac:effet sur l'immunitéIndex. décimale : TA 3.2.2.2.1 Interactions avec d'autres facteurs pathogènes Résumé : The cholinergic nervous system can inhibit the systemic inflammation accompanying sepsis by virtue of a specific action of acetylcholine on alpha7 cholinergic receptors. The current authors sought to determine the effect of nicotine, an alpha7 cholinergic receptor agonist, on the host response to pneumonia caused by Streptococcus pneumoniae. Mice were intranasally infected with S. pneumoniae and treated with nicotine or saline intraperitoneally using a treatment schedule shown to improve host defence against abdominal sepsis. Nicotine treatment was associated with a transiently enhanced growth of S. pneumoniae, as indicated by higher bacterial loads in both lungs and blood at 24 h after infection. At 48 h after infection, bacterial burdens had increased in both treatment groups and differences were no longer present. Remarkably, mice treated with nicotine showed enhanced lung inflammation at 24 h after infection. Moreover, both lung and plasma concentrations of the pro-inflammatory cytokines tumour necrosis factor-alpha and interferon-gamma were higher in nicotine-treated animals at this time-point. Additional studies examining the effect of nicotine on the immediate (4-h) inflammatory response to S. pneumoniae did not reveal an anti-inflammatory effect of nicotine either. The present data suggest that nicotine transiently impairs host defence in pneumococcal pneumonia. En ligne : https://erj.ersjournals.com/content/33/2/375 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8064 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Systemic sensitivity to corticosteroids in smokers with asthma Type de document : texte imprimé Auteurs : E. Livingston, Auteur ; R. Chaudhuri, Auteur ; A.D. McMahon, Auteur ; T. Fraser, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2007 Collection : European Respiratory Journal num. 29 Importance : p. 64-70 Langues : Anglais (eng) Catégories : [PROMOSAN] allergie:traitement de l'allergie:corticoïde
[TABAC] étude
[TABAC] tabagisme:pathologie:pathologie respiratoire:asthmeIndex. décimale : TA 3.2.2.2.2 Interactions avec des médicaments Résumé : Cigarette smokers with asthma are insensitive to the therapeutic effects of corticosteroids. It is not known whether this insensitivity to corticosteroids in smokers affects tissue sites beyond the airways.
A total of 75 asthmatic subjects (39 smokers) and 78 healthy controls (30 smokers) were recruited to an observational study. The cutaneous and peripheral blood lymphocyte responses to corticosteroids were measured. The cutaneous vasoconstrictor response to topical beclometasone was measured by applying different concentrations of beclometasone solutions to the skin in a random double-blind manner. The degree of blanching at each concentration was graded after 18 h. The sensitivity of peripheral blood lymphocytes to corticosteroids was assessed by measuring the suppressive effect of dexamethasone on lymphocyte proliferation stimulated by phytohaemagglutinin (PHA).
Total mean±sd cutaneous vasoconstrictor response score to beclometasone was reduced in smokers with asthma to 5.39±3.58 versus 7.26±3.05 in never-smokers with asthma; and in all smokers to 6.47±3.33 versus 7.86±2.81 in all never-smokers. The sensitivity to corticosteroids of lymphocytes stimulated by PHA was similar between groups.
In conclusion, smokers with asthma have an impaired cutaneous vasoconstrictor response to topical corticosteroids compared with never-smokers with asthma. This finding suggests that the insensitivity to corticosteroids in smokers with asthma affects tissue sites other than the airways.
En ligne : https://erj.ersjournals.com/content/29/1/64 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8067 Aucun avis, veuillez vous identifier pour ajouter le vôtre !