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American Journal of respiratory and critical care medicine
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Ajouter le résultat dans votre panier Affiner la rechercheSmoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma / Stephen C. Lazarus (2007)
Titre : Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma Type de document : document électronique Auteurs : Stephen C. Lazarus, Auteur ; Vernon M. Chinchilli, Auteur ; Nancy J. Rollings, Auteur Editeur : American Thoracic Society Année de publication : 2007 Collection : American Journal of respiratory and critical care medicine num. 175 Importance : p. 783-790 Présentation : graph., tab Langues : Anglais (eng) Catégories : [TABAC] tabagisme:pathologie:pathologie respiratoire:asthme
[TABAC] tabagisme:tabagisme actifMots-clés : Traitement hors NRT Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Rationale:
One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control.
Objectives:
To determine if the response to an inhaled corticosteroid or a leukotriene receptor antagonist is attenuated in individuals with asthma who smoke.
Methods:
In a multicenter, placebo-controlled, double-blind, doubledummy, crossover trial, 44 nonsmokers and 39 light smokers with mild asthma were assigned randomly to treatment twice daily with inhaled beclomethasone and once daily with oral montelukast.
Measurements and Main Results:
Primary outcome was change in prebronchodilator FEV1 in smokers versus nonsmokers. Secondary outcomes included peak flow, PC20 methacholine, symptoms, quality
of life, and markers of airway inflammation. Despite similar FEV1, bronchodilator response, and sensitivity to methacholine at baseline, subjects with asthma who smoked had significantly more symptoms, worse quality of life, and lower daily peak flow than nonsmokers. Adherence to therapy did not differ significantly between
smokers and nonsmokers, or between treatment arms. Beclomethasone significantly reduced sputum eosinophils and eosinophil cationic protein (ECP) in both smokers and nonsmokers, but increased FEV1 (170 ml, p ? 0.0003) only in nonsmokers. Montelukast significantly increased A.M. peak flow in smokers (12.6 L/min, p ? 0.002), but not in nonsmokers.
Conclusions:
In subjects with mild asthma who smoke, the response to inhaled corticosteroids is attenuated, suggesting that adjustments to standard therapy may be required to attain asthma control. The greater improvement seen in some outcomes in smokers treated with montelukast suggests that leukotrienes may be important in this setting. Larger prospective studies are required to determine whether leukotriene modifiers can be recommended for managing asthma in patients who smoke.En ligne : https://DOI.org/10.1164/rccm.200511-1746OC Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9728 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
The effect of maternal smoking during pregnancy on early infant lung function / John P. Hanrahan (01 May 1992)
Titre : The effect of maternal smoking during pregnancy on early infant lung function Type de document : texte imprimé Auteurs : John P. Hanrahan, Auteur ; Ira B. Tager, Auteur ; Mark R. Segal, Auteur ; Tor D. Tosteson, Auteur ; Robert G. Castile, Auteur ; Helen Van Vunakis, Auteur ; Scott T. Weiss, Auteur ; Frank E. Speizer, Auteur Editeur : American Thoracic Society Année de publication : 01 May 1992 Collection : American Journal of respiratory and critical care medicine num. Vol. 145, N°5 Importance : P. 1129 - 1135 Langues : Français (fre) Catégories : [TABAC] tabagisme:risque:facteur associé:grossesse:foetus
[TABAC] tabagisme:tabagisme actif:tabagisme féminin:tabagisme durant la grossesseIndex. décimale : TA 3.2.2.7 Grossesse et fœtus Résumé : We studied the effect of prenatal maternal cigarette smoking on the pulmonary function (PF) of 80 healthy infants tested shortly after birth (mean, 4.2 +/- 1.9 wk). Mothers' prenatal smoking was measured by: (1) questionnaire reports at each prenatal visit of the number of cigarettes smoked per day, and (2) urine cotinine concentrations (corrected for creatinine) obtained at each visit. Infant PF was assessed by partial expiratory flow-volume curves and helium-dilution measurement of FRC. Forced expiratory flow rates were significantly lower in infants born to smoking mothers, both when unadjusted and after controlling for infant size, age, sex, and passive exposure to environmental tobacco smoke (ETS) between birth and the time of PF testing. Flow at functional residual capacity (VFRC) in infants born to smoking mothers was lower than that found in infants whose mothers did not smoke during pregnancy (74.3 +/- 15.9 versus 150.4 +/- 8.9 ml/s; p = 0.0007). Differences remained significant when flow was corrected for lung size (VFRC/FRC: 0.87 +/- 0.26 versus 1.77 +/- 0.12 s-1; p = 0.013). No differences in pulmonary function were evident among infants exposed and unexposed to ETS in the home after stratifying by prenatal exposure status. We conclude that maternal smoking during pregnancy is associated with significant reductions in forced expiratory flow rates in young infants. The results suggest that maternal smoking during pregnancy may impair in utero airway development and/or alter lung elastic properties. We speculate that these effects of maternal prenatal smoking on early levels of forced expiratory flow may be an important factor predisposing infants to the occurrence of wheezing illness later in childhood. Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8233 Exemplaires (1)
Code-barres Cote Support Localisation Section Disponibilité TA 005740 TA 3.2.2.7 HAN E Article/Périodique Bibliothèque FARES Tabac Consultation sur place
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Titre : Tuberculosis contact investigations : please don’t fail me now Type de document : document électronique Auteurs : Charles L. Daley, Auteur Editeur : American Thoracic Society Année de publication : 2004 Collection : American Journal of respiratory and critical care medicine num. vol. 169 issue 7 Importance : p.779-781 Langues : Anglais (eng) Catégories : [DIVERS] personne
[TUBER] dépistage
[TUBER] type de tuberculose:tuberculose-maladieIndex. décimale : TU 3.7. Dépistage En ligne : https://doi.org/10.1164/rccm.2401012 Format de la ressource électronique : HTML, PDF Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9378 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
