| Titre : |
Effectiveness of smoking cessation therapies : a systematic review and meta-analysis |
| Type de document : |
texte imprimé |
| Auteurs : |
Ping Wu, Auteur ; Kumanan Wilson, Auteur ; Popey Dimoulas, Auteur |
| Editeur : |
BioMed Central |
| Année de publication : |
2006 |
| Collection : |
BMC Public Health num. Vol. 6 |
| Importance : |
16 p. |
| Présentation : |
tab., ill. |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] étude
[TABAC] étude:méta-analyse
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:bupropion
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:substitution nicotinique
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:varénicline
|
| Index. décimale : |
TA 6.2.3 Approche pharmacologique |
| Résumé : |
BACKGROUND:
Smoking remains the leading preventable cause of premature deaths. Several pharmacological interventions now exist to aid smokers in cessation. These include Nicotine Replacement Therapy [NRT], bupropion, and varenicline. We aimed to assess their relative efficacy in smoking cessation by conducting a systematic review and meta-analysis.
METHODS:
We searched 10 electronic medical databases (inception to Sept. 2006) and bibliographies of published reviews. We selected randomized controlled trials [RCTs] evaluating interventions for smoking cessation at 1 year, through chemical confirmation. Our primary endpoint was smoking cessation at 1 year. Secondary endpoints included short-term smoking cessation (approximately 3 months) and adverse events. We conducted random-effects meta-analysis and meta-regression. We compared treatment effects across interventions using head-to-head trials and when these did not exist, we calculated indirect comparisons.
RESULTS:
We identified 70 trials of NRT versus control at 1 year, Odds Ratio [OR] 1.71, 95% Confidence Interval [CI], 1.55-1.88, P =
CONCLUSION:
NRT, bupropion and varenicline all provide therapeutic effects in assisting with smoking cessation. Direct and indirect comparisons identify a hierarchy of effectiveness. |
| En ligne : |
https://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-6-300 |
| Format de la ressource électronique : |
HTML |
| Permalink : |
http://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=7965 |
Effectiveness of smoking cessation therapies (2006)
