| Titre : |
Evaluation of cytotoxic and genotoxic effects in buccal mucosal cells in non-smokers and users of traditional combustible tobacco products and non-combustible alternatives |
| Type de document : |
document électronique |
| Auteurs : |
Antonija Tadin, Auteur ; Vinka Stazic, Auteur ; Nada Galic, Auteur ; Davor Zeljezic, Auteur |
| Editeur : |
Bâle [Suisse] : MDPI AG (Molecular Diversity Preservation International) |
| Année de publication : |
2024 |
| Collection : |
Journal of xenobiotics num. 14 |
| Importance : |
p. 155-165 |
| Présentation : |
graph., tab. |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] CANDIDATS:e-cigarette
[TABAC] étude
[TABAC] tabagisme:effet du tabac:effet bucco-dentaire
[TABAC] tabagisme:effet du tabac:toxicité
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| Index. décimale : |
TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) |
| Résumé : |
Aims/Objectives: The aim of this cross-sectional observational study was to investigate cytogenetic damage to the buccal mucosa in non-smokers and consumers of traditional combustible tobacco products and non-combustible alternatives.
Methods: A total of 160 participants were divided into four groups according to the type of product used, including non-smokers, users of conventional combustible tobacco (cigarettes), heated tobacco, and electronic, tobacco-free vapor products (e-cigarettes). Buccal mucosa samples were analyzed using the micronucleus cytome assay
to assess cytotoxic and genotoxic damage.
Results: E-cigarette users showed significantly higher values for all tested parameters in the micronucleus test compared to non-smokers (p < 0.05). Similarly, users of tobacco heating products showed an increase in all parameters (p < 0.05), with the exception of the number of cells with micronuclei. Conventional cigarette smokers showed a notable increase in the number of binucleated cells and cells with karyorrhexis and karyolysis (p ≤ 0.05). When assessing the differences between users of traditional combustible tobacco products and non-combustible alternatives, these did not appear to be significant, except for e-cigarette users, who had significantly more cells with condensed chromatin (p ≤ 0.001), while users of tobacco heating products had more pyknotic cells (p ≤ 0.001).
Conclusion: The results of this study underscore the heightened occurrence of cytotoxic and genotoxic damage in users of both conventional combustible tobacco products and non-combustible alternatives compared to non-smokers, emphasizing the detrimental impact of these products on the oral mucosa.
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Evaluation of cytotoxic and genotoxic effects in buccal mucosal cells in non-smokers and users of traditional combustible tobacco products and non-combustible alternatives (2024)
