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Ajouter le résultat dans votre panier Affiner la rechercheAssessing the impact of protonating acid combinations in e‑cigarette liquids / Justin Frosina (2023)
Titre : Assessing the impact of protonating acid combinations in e‑cigarette liquids : a randomised, crossover study on nicotine pharmacokinetics Type de document : document électronique Auteurs : Justin Frosina, Auteur ; Michael McEwan, Auteur ; James Ebajemito, Auteur ; Jesse Thissen, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 11 p. Présentation : graph,tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étudeMots-clés : Pharmacocinétique - e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : The addition of protonating acids to e-cigarette liquid formulations (e-liquids) enhances nicotine bioavailability in e-cigarette use. However, little is known about the impact of different combinations of protonating acid on nicotine pharmacokinetics. The objectives of this study were to compare pharmacokinetics of nicotine absorption following use of a closed-system e-cigarette, containing e-liquids with two different nicotine levels and with different ratios of three common protonating acids—lactic, benzoic and levulinic. In a randomised, controlled, crossover study, nicotine pharmacokinetics and product liking were assessed for prototype e-liquids used in a Vuse e-cigarette containing either 3.5% or 5% nicotine and varying ratios of lactic, benzoic and/or levulinic acid. During an 8-day confinement period, 32 healthy adult current cigarette smokers/e-cigarette dual users used a single study e-liquid each day during 10-min fixed and ad libitum use periods after overnight nicotine abstinence. For most comparisons, Cmax and AUC 0–60 following both fixed and ad libitum puffing were significantly higher for e-liquids containing 5% nicotine compared with 3.5% nicotine. However, Cmax and AUC 0–60 were not statistically different for 5% nicotine e-liquids containing varying ratios of lactic, levulinic and benzoic acid when compared to an e-liquid containing lactic acid only. Mean scores for product liking were similar for all e-liquid formulations assessed, regardless of nicotine concentration, acid content, and whether the product was used in a fixed or ad libitum puffing regimen. While e-liquid nicotine concentration significantly affected users’ nicotine uptake, the different combinations of benzoic, levulinic and lactic acid in the e-liquids assessed had limited impact on nicotine pharmacokinetics and product liking scores. En ligne : https://doi.org/10.1186/s43162-024-00274-z Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10257 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Carcinogenic and non‑carcinogenic health risk assessment of organic compounds and heavy metals in electronic cigarettes Type de document : document électronique Auteurs : Siyuan Zhao, Auteur ; Xi Zhang, Auteur ; Junji Wang, Auteur ; Jianzai Lin, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 13 p. Présentation : tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:fumée:acétone
[TABAC] chimie du tabac:fumée:acroléine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étude
[TABAC] tabagisme:risqueIndex. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : E-cigarettes are now very popular in the world. Compared to traditional cigarettes, e-cigarettes are often considered safer and healthier. However, their safety remains controversial and requires further research and regulation. In this study, we aimed to understand the possible hazards to humans of four compounds (formaldehyde, acetaldehyde, acrolein, and acetone) and seven heavy metals (arsenic, cadmium, manganese, lead, copper, nickel, and chromium) contained in e-cigarette liquids and aerosols and perform a health risk assessment. We searched PubMed, CNKI, and other databases for relevant literature to obtain data on organic compounds and heavy metals in e-cigarette liquids and aerosols, and conducted acute, chronic, and carcinogenic risk assessments of various chemicals by different exposure routes. This study showed that exposure to four organic compounds and seven heavy metals in e-cigarette aerosols and e-liquids can cause varying levels of health risks in humans through different routes, with the inhalation route posing a higher overall risk than dermal exposure and oral intake. Various chemicals at high exposure doses can produce health risks beyond the acceptable range. E-cigarette designers must improve their products by changing the composition of the e-liquid and controlling the power of the device to reduce the health effects on humans. En ligne : https://doi.org/10.1038/s41598-023-43112-y Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10256 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Forecasting vaping health risks through neural network model prediction of flavour pyrolysis reactions Type de document : document électronique Auteurs : Akihiro Kishimoto, Auteur ; Dan Wu, Auteur ; Donal F. O’Shea, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports num. 14 Importance : 14 p. Présentation : graph., tab., ill. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac
[TABAC] chimie du tabac:constituant:additif:agent de saveur
[TABAC] tabagisme:effet du tabac:effet neurologiqueMots-clés : e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Vaping involves the heating of chemical solutions (e-liquids) to high temperatures prior to lung inhalation. A risk exists that these chemicals undergo thermal decomposition to new chemical
entities, the composition and health implications of which are largely unknown. To address this concern, a graph-convolutional neural network (NN) model was used to predict pyrolysis reactivity
of 180 e-liquid chemical flavours. The output of this supervised machine learning approach was a dataset of probability ranked pyrolysis transformations and their associated 7307 products. To refine this dataset, the molecular weight of each NN predicted product was automatically correlated with experimental mass spectrometry (MS) fragmentation data for each flavour chemical. This blending of deep learning methods with experimental MS data identified 1169 molecular weight matches that prioritized these compounds for further analysis. The average number of discrete matches per flavour between NN predictions and MS fragmentation was 6.4 with 92.8% of flavours having at least one match. Globally harmonized system classifications for NN/MS matches were extracted
from PubChem, revealing that 127 acute toxic, 153 health hazard and 225 irritant classifications were predicted. This approach may reveal the longer-term health risks of vaping in advance of clinical diseases emerging in the general population.En ligne : https://doi.org/10.1038/s41598-024-59619-x Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10289 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Health warning labels on heated tobacco products and their impact on use intentions and risk perceptions : a cross‑sectional study of adult tobacco users in the US and Israel Type de document : document électronique Auteurs : Zongshuan Duan, Auteur ; Hagai Levine, Auteur ; Yael Bar‑Zeev, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Israel Journal of Health Policy Research Importance : 10 p. Présentation : tab.,graph., Langues : Anglais (eng) Catégories : [DIVERS] géographie:Amérique:Amérique du Nord:Etats-Unis
[TABAC] chimie du tabac:tabac non fumé:tabac chauffé
[TABAC] économie du tabac:fabrication du tabac:étiquetage:avertissement sanitaire
[TABAC] étude
[TABAC] prévention:stratégieMots-clés : Israël Index. décimale : TA 9.3.4 Avertissements sanitaires Résumé : Background
Health warning labels (HWLs) represent an evidence-based tobacco control strategy; however, their
application to heated tobacco products (HTPs) and related impacts are understudied. This study examined the impact of HTP HWLs on HTP use intentions and risk perceptions among current tobacco users.
Methods
We analyzed cross-sectional survey data from adults in the US and Israel reporting past-month tobacco use and awareness of HTPs (N = 424). Multivariate analyses examined: (1) sociodemographics in relation to self-reported impact of HTP HWLs (i.e., more concerned about HTP use, reassured, no effect [referent]) among those who noticed HTP HWLs (multinomial regressions); and (2) HWL impacts in relation to HTP use intentions and perceived addictiveness and harm (linear regressions).
Results Among participants who noticed HTP HWLs (n = 372, 87.7%), 27.7% reported HWLs increased their concerns about HTP use, 22.6% were reassured about use, and 49.7% reported no effect. Factors associated with increased concern (vs. no effect) included other tobacco product use (aOR = 2.10, 95% CI 1.21–3.64) and being female (aOR = 1.77, 95% CI 1.03–3.05). Factors associated with being reassured about HTPs use (vs. no effect) included current HTP use (aOR = 2.11, 95% CI 1.11–4.00) and being from Israel (vs. US: aOR = 3.85, 95% CI 1.85–7.69), female (aOR = 1.91, 95% CI 1.07–3.42), and less educated (< college education: aOR = 2.57, 95% CI 1.42–4.63). Reporting that HWLs on HTPs increased concern (β = 0.46, 95% CI 0.03–0.89) and reassured of use (β = 0.94, 95% CI 0.47–1.41) were positively associated with HTP use intentions; no associations with risk perceptions were found.
Conclusions
Findings indicate that most tobacco users noticed HWLs on HTPs, but the majority reported no effect or being reassured of using HTPs, effects that were magnified for specific subgroups. Both increased concern and reassurance correlated with greater use intentions. Additional research should evaluate HTP HWL impacts and ensure effectiveness in communicating risks and discouraging use.En ligne : https://doi.org/10.1186/s13584-023-00582-9 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10262 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Immunology in COPD and the use of combustible cigarettes and heated tobacco products Type de document : document électronique Auteurs : Justyna Błach, Auteur ; Mateusz Siedliński, Auteur ; Wojciech Sydor, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : European Journal of Medical Research Importance : 10 p. Présentation : ill. Langues : Anglais (eng) Catégories : [TABAC] tabagisme:pathologie:pathologie respiratoire:broncho-pneumopathie chronique obstructive Index. décimale : TA 3.2.2.4 Pathologies respiratoires Résumé : Chronic obstructive pulmonary disease (COPD) is one of the most common chronic respiratory diseases, characterised by high morbidity and mortality. COPD is characterised by a progressive decline of lung function caused by chronic inflammatory reactions in the lung tissue due to continual exposure to harmful molecules by inhalation. As prevention plays a very important role in COPD, quitting smoking is the most important factor in reducing the decline in lung function. Unfortunately, many people are unable to break their nicotine addiction. This paper summarises current knowledge about combustible cigarettes (CSs) and alternative tobacco products such as heated tobacco products (HTPs) in COPD. The paper focuses on the immunological aspects of COPD and the influence of tobacco products on lung tissue immunology. There are differences in research results between HTPs and CSs in favour of HTPs. More long-term studies are needed to look at the effects of HTPs, especially in COPD. However, there is no doubt that it would be best for patients to give up their nicotine addiction completely. En ligne : https://doi.org/10.1186/s40001-023-01374-2 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10260 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Marketing claims, promotional strategies, and product information on Malaysian e-cigarette retailer websites-a content analysis Type de document : document électronique Auteurs : Sameeha Misriya Shroff, Auteur ; Chandrashekhar T Sreeramareddy, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Substance Abuse Treatment, Prevention, and Policy Importance : 9 p. Présentation : tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] économie du tabac:marketing
[TABAC] législationMots-clés : e-commerce - Malaisie Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Background
Marketing and sales of e-cigarettes are unregulated in Malaysia. We analyzed content displayed on e-cigarette retailer websites to identify marketing claims, promotional strategies, and product details in the year 2022.
Methods
We analyzed 30 Malaysia-based retailer websites using a mixed methods approach. Data were extracted as the frequency of occurrences of marketing claims, presence of regulatory information, product types, and flavors of e-juice as per a predefined codebook based on published literature. We also extracted textual details published on the websites about marketing claims, and slogans.
Results
Most retailer websites provided contact information and physical store addresses (83%) but only half had ‘click through’ age verification (57%) that seldom needed any identification proof for age (3%). Marketing claims were related to health (47%), smoking cessation (37%), and modernity/trend (37%) and none had health warnings.
Promotional strategies were discounts (80%). starter kits (57%) and email subscriptions (53%). Product types displayed were rechargeable (97%) and disposable (87%) devices and e-liquids (90%) of an array of flavors (> 100). Nicotine presence, its concentration, and “nicotine is an addictive chemical” were displayed in 93%, 53%, and 23% of websites respectively.
Conclusion
Surveillance of content displayed online on e-cigarette retailer websites and regulation of online marketing and sales should be implemented by the Ministry of Health, Malaysia. Such measures are needed to prevent access to, and initiation of e-cigarette use among the youth and adults who do not smoke.En ligne : https://doi.org/10.1186/s13011-024-00592-z Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10229 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Physical and chemical characterizations of a reference e‑cigarette used in animal testing Type de document : document électronique Auteurs : Sébastien Soulet, Auteur ; Léa Constant, Auteur ; Vanille Quinty, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 10 p. Présentation : graph. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étudeMots-clés : Expérimentation animale :-(
caractéristiques physiques... du produitIndex. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : A minimal necessary condition for preclinical studies to contribute to risk assessments of e-cigarettes (ECs) is the ability to expose laboratory animals to an appropriate dosage of aerosols. In this study, we examined the fulfilment of this essential consistency condition for the ECX-Joyetech E-Vic Mini (ECX),a piece of computerized exposure equipment manufactured by SCIREQ, which has been employed by numerous in vivo testing. We began by calibrating the customary Evic VTC mini device mod and the 4 coils available, reproducing in the laboratory the operation of the ECX in the power-control and temperature-control modes, using puffing parameters recommended by its documentation. We then conducted the following tests for each coil: (1) verifying whether the generated aerosols satisfy an optimal operational regime, free from overheating, as determined by a linear relation between the mass of vaporized e-liquid vs. supplied power and (2) obtaining the mean yields of aldehydes for each of the tested power settings and coils. The results of these tests show that, under the main conditions used in in vivo testing, the ECX equipment fails to comply with these consistency requirements, especially for coils with low subohm resistance, a shortcoming that can be corrected by applying much larger airflows for these coils. Therefore, the outcomes of preclinical studies using the ECX equipment should be examined with great scepticism and subjected to further testing. En ligne : https://doi.org/10.1038/s41598-023-43733-3 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10255 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Risks and benefits of nicotine to aid smoking cessation in pregnancy Type de document : texte imprimé Auteurs : Delia A. Dempsey, Auteur ; Neal L. Benowitz, Auteur Editeur : Springer Nature Année de publication : 2001 Collection : Drug Safety, ISSN 0114-5916 num. 24 Importance : p.277-322 Langues : Anglais (eng) Catégories : [TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:substitution nicotinique
[TABAC] tabagisme:évaluation du tabagisme:test de dépendance à la nicotine
[TABAC] tabagisme:risque:facteur associé:grossesse
[TABAC] tabagisme:tabagisme actif:tabagisme féminin:tabagisme durant la grossesseIndex. décimale : TA 6.7 Facteurs influents (grossesse, adolescence…) Résumé : Cigarette smoking during pregnancy is the single largest modifiable risk for pregnancy-related morbidity and mortality in the US. Addiction to nicotine prevents many pregnant women who wish to quit smoking from doing so. The safety and efficacy of nicotine replacement therapy (NRT) for smoking cessation during pregnancy have not been well studied. En ligne : https://doi.org/10.2165/00002018-200124040-00005 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10394 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex Type de document : document électronique Auteurs : Joseph O'Neill, Auteur ; Maylen Perez Diaz, Auteur ; Jeffry R. Alger, Auteur ; Jean-Baptiste Pochon, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Molecular Psychiatry Importance : 10 p. Présentation : tab., ill., graph. Langues : Anglais (eng) Catégories : [DIVERS] anatomie:corps humain:système nerveux:cerveau
[TABAC] tabagisme:effet du tabac:effet neurologiqueIndex. décimale : TA 3.2.2.6 Effets métaboliques et biologiques Résumé : Cigarette smoking has a major impact on global health and morbidity, and positron emission tomographic research has provided evidence for reduced inflammation in the human brain associated with cigarette smoking. Given the consequences of inflammatory dysfunction for health, the question of whether cigarette smoking affects neuroinflammation warrants further investigation.
The goal of this project therefore was to validate and extend evidence of hypoinflammation related to smoking, and to examine the potential contribution of inflammation to clinical features of smoking. Using magnetic resonance spectroscopy, we measured levels of neurometabolites that are putative neuroinflammatory markers. N-acetyl compounds (N-acetylaspartate + Nacetylaspartylglutamate), glutamate, creatine, choline-compounds (phosphocholine + glycerophosphocholine), and myo-inositol, have all been linked to neuroinflammation, but they have not been examined as such with respect to smoking. We tested whether people who smoke cigarettes have brain levels of these metabolites consistent with decreased neuroinflammation, and whether clinical features of smoking are associated with levels of these metabolites. The dorsal anterior cingulate cortex was chosen as the region-of-interest because of previous evidence linking it to smoking and related states.
Fifty-four adults who smoked daily maintained overnight smoking abstinence before testing and were compared with 37 nonsmoking participants. Among the smoking participants, we tested for associations of metabolite levels with tobacco dependence, smoking history, craving, and withdrawal. Levels of N-acetyl compounds and glutamate were higher, whereas levels of creatine and choline compounds were lower in the smoking group as compared with the nonsmoking group. In the smoking group, glutamate and creatine levels correlated negatively with tobacco dependence, and creatine correlated negatively with lifetime smoking, but none of the metabolite levels correlated with craving or withdrawal. The findings indicate a link between smoking and a hypoinflammatory state in the brain, specifically in the dorsal anterior cingulate cortex. Smoking may thereby increase vulnerability to infection and brain injury.
En ligne : https://doi.org/10.1038/s41380-023-02247-0 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10259 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : The combination of propylene glycol and vegetable glycerin e‑cigarette aerosols induces airway inflammation and mucus hyperconcentration Type de document : document électronique Auteurs : Michael D. Kim, Auteur ; Samuel Chung, Auteur ; Nathalie Baumlin, Auteur ; Jian Qian, Auteur ; Robert N. Montgomery, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports num. 14 - 1942 Importance : 14 p. Présentation : graph., ill. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] tabagisme:pathologie:pathologie respiratoire
[TABAC] tabagisme:risqueMots-clés : e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Despite concerns over their safety, e-cigarettes (e-cigs) remain a popular tobacco product. Although nicotine and flavors found in e-cig liquids (e-liquids) can cause harm in the airways, whether the delivery vehicles propylene glycol (PG) and vegetable glycerin (VG) are innocuous when inhaled remains unclear. Here, we investigated the effects of e-cig aerosols generated from e-liquid containing only PG/VG on airway inflammation and mucociliary function in primary human bronchial epithelial cells (HBEC) and sheep. Primary HBEC were cultured at the air–liquid interface (ALI) and exposed to e-cig aerosols of 50%/50% v/v PG/VG. Ion channel conductance, ciliary beat frequency, and the expression of inflammatory markers, cell type-specific markers, and the major mucins MUC5AC and MUC5B were evaluated after seven days of exposure. Sheep were exposed to e-cig aerosols of PG/VG for five days and mucus concentration and matrix metalloproteinase-9 (MMP-9) activity were measured from airway secretions. Seven-day exposure of HBEC to e-cig aerosols of PG/VG caused a significant reduction in the activities of apical ion channels important for mucus hydration, including the cystic fibrosis transmembrane conductance regulator (CFTR) and large conductance, Ca2+- activated, and voltage-dependent K+ (BK) channels. PG/VG aerosols significantly increased the mRNA expression of the inflammatory markers interleukin-6 (IL6), IL8, and MMP9, as well as MUC5AC.The increase in MUC5AC mRNA expression correlated with increased immunostaining of MUC5AC protein in PG/VG-exposed HBEC. On the other hand, PG/VG aerosols reduced MUC5B expression leading overall to higher MUC5AC/MUC5B ratios in exposed HBEC. Other cell type-specific markers, including forkhead box protein J1 (FOXJ1), keratin 5 (KRT5), and secretoglobin family 1A member 1 (SCGB1A1) mRNAs, as well as overall ciliation, were significantly reduced by PG/VG exposure. Finally,
PG/VG aerosols increased MMP-9 activity and caused mucus hyperconcentration in sheep in vivo. E-cig aerosols of PG/VG induce airway inflammation, increase MUC5AC expression, and cause dysfunction
of ion channels important for mucus hydration in HBEC in vitro. Furthermore, PG/VG aerosols increase MMP-9 activity and mucus concentration in sheep in vivo. Collectively, these data show that e-cig aerosols containing PG/VG are likely to be harmful in the airways.
En ligne : https://doi.org/10.1038/s41598-024-52317-8 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10227 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
