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Ajouter le résultat dans votre panier Affiner la rechercheAssessing the impact of protonating acid combinations in e‑cigarette liquids / Justin Frosina (2023)
Titre : Assessing the impact of protonating acid combinations in e‑cigarette liquids : a randomised, crossover study on nicotine pharmacokinetics Type de document : document électronique Auteurs : Justin Frosina, Auteur ; Michael McEwan, Auteur ; James Ebajemito, Auteur ; Jesse Thissen, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 11 p. Présentation : graph,tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étudeMots-clés : Pharmacocinétique - e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : The addition of protonating acids to e-cigarette liquid formulations (e-liquids) enhances nicotine bioavailability in e-cigarette use. However, little is known about the impact of different combinations of protonating acid on nicotine pharmacokinetics. The objectives of this study were to compare pharmacokinetics of nicotine absorption following use of a closed-system e-cigarette, containing e-liquids with two different nicotine levels and with different ratios of three common protonating acids—lactic, benzoic and levulinic. In a randomised, controlled, crossover study, nicotine pharmacokinetics and product liking were assessed for prototype e-liquids used in a Vuse e-cigarette containing either 3.5% or 5% nicotine and varying ratios of lactic, benzoic and/or levulinic acid. During an 8-day confinement period, 32 healthy adult current cigarette smokers/e-cigarette dual users used a single study e-liquid each day during 10-min fixed and ad libitum use periods after overnight nicotine abstinence. For most comparisons, Cmax and AUC 0–60 following both fixed and ad libitum puffing were significantly higher for e-liquids containing 5% nicotine compared with 3.5% nicotine. However, Cmax and AUC 0–60 were not statistically different for 5% nicotine e-liquids containing varying ratios of lactic, levulinic and benzoic acid when compared to an e-liquid containing lactic acid only. Mean scores for product liking were similar for all e-liquid formulations assessed, regardless of nicotine concentration, acid content, and whether the product was used in a fixed or ad libitum puffing regimen. While e-liquid nicotine concentration significantly affected users’ nicotine uptake, the different combinations of benzoic, levulinic and lactic acid in the e-liquids assessed had limited impact on nicotine pharmacokinetics and product liking scores. En ligne : https://doi.org/10.1186/s43162-024-00274-z Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10257 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Carcinogenic and non‑carcinogenic health risk assessment of organic compounds and heavy metals in electronic cigarettes Type de document : document électronique Auteurs : Siyuan Zhao, Auteur ; Xi Zhang, Auteur ; Junji Wang, Auteur ; Jianzai Lin, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 13 p. Présentation : tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:fumée:acétone
[TABAC] chimie du tabac:fumée:acroléine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étude
[TABAC] tabagisme:risqueIndex. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : E-cigarettes are now very popular in the world. Compared to traditional cigarettes, e-cigarettes are often considered safer and healthier. However, their safety remains controversial and requires further research and regulation. In this study, we aimed to understand the possible hazards to humans of four compounds (formaldehyde, acetaldehyde, acrolein, and acetone) and seven heavy metals (arsenic, cadmium, manganese, lead, copper, nickel, and chromium) contained in e-cigarette liquids and aerosols and perform a health risk assessment. We searched PubMed, CNKI, and other databases for relevant literature to obtain data on organic compounds and heavy metals in e-cigarette liquids and aerosols, and conducted acute, chronic, and carcinogenic risk assessments of various chemicals by different exposure routes. This study showed that exposure to four organic compounds and seven heavy metals in e-cigarette aerosols and e-liquids can cause varying levels of health risks in humans through different routes, with the inhalation route posing a higher overall risk than dermal exposure and oral intake. Various chemicals at high exposure doses can produce health risks beyond the acceptable range. E-cigarette designers must improve their products by changing the composition of the e-liquid and controlling the power of the device to reduce the health effects on humans. En ligne : https://doi.org/10.1038/s41598-023-43112-y Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10256 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : E-cigarette-associated acute severe asthma in a smoking-naïve adolescent : a case report Type de document : document électronique Auteurs : Lucas Küppers, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Cureus, ISSN 2168-8184 num. 16(8) Importance : p. 1-5 Présentation : graph.; tab Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] prévention:santé
[TABAC] tabagisme:pathologie:cancer
[TABAC] tabagisme:pathologie:pathologie cardio-vasculaire
[TABAC] tabagisme:pathologie:pathologie respiratoire:asthme
[TABAC] tabagisme:risque
[TABAC] tabagisme:tabagisme actif:tabagisme adolescentIndex. décimale : TA 2.4.1 Enfants et jeunes Résumé : Electronic cigarettes (e-cigarettes) have become a prevalent phenomenon among adolescents and young adults, particularly as a perceived less harmful alternative to traditional tobacco cigarettes. A number of potential health risks associated with e-cigarettes have been identified, including links to cardiovascular diseases, asthma, and cancer. Given that adolescents have not yet completed their physical development, they are particularly susceptible to adverse health effects associated with e-cigarettes. This case report details the presentation of a healthy 16-year-old female patient who developed her first episode of acute severe asthma and a concomitant lower respiratory tract infection in a primary care practice setting. Prior to the onset of her symptoms, the smoking-naïve patient intermittently shared a nicotine-containing e cigarette with a friend over a three-day period. Following outpatient treatment with inhaled corticosteroids, beta-2 agonists, and antibiotics, the asthma and lower respiratory tract infection were found to be reversible within the first week of treatment initiation. It is imperative that preventive measures at the political level be implemented to counteract the appeal and use of e-cigarettes among adolescents. En ligne : https://www.doi.org/10.7759/cureus.67422 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10473 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Emissions from conventional and electronic waterpipes relative to cigarettes and a heated tobacco product Type de document : document électronique Auteurs : Peter J. Wilkinson, Auteur ; A Clarke, Auteur ; Ian M. Fearon, Auteur ; Ronan Barry, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports Importance : p. 1-16 Présentation : graph.; tab. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:substance toxique
[TABAC] chimie du tabac:tabac fumé:chicha
[TABAC] étude
[TABAC] tabagisme:risqueIndex. décimale : TA 1.1.4 Chicha – Narguilé Résumé : Harms associated with tobacco product use, including waterpipe, are due to inhalational exposure to toxicants either present in tobacco or formed during the process of combustion. We assessed levels of 37 toxicants in aerosol emissions from conventional waterpipe heated with different charcoals and also with a heat management device (HMD), from the IQOS heated tobacco product (HTP), and the ‘OOKA’ electronic waterpipe. We also utilised literature data on toxicant yields in 3R4F reference cigarette smoke. When taking use patterns into account, toxicant yields were substantially lower in conventional waterpipe aerosol compared with cigarette smoke. Toxicant yields in electronic waterpipe aerosol were substantially lower than those in conventional waterpipe aerosol, both on a per session basis and when taking typical use patterns into account. Numerous toxicants in conventional waterpipe aerosol were absent in electronic waterpipe aerosol. In summary, during typical use conventional waterpipe emits fewer, and lower levels of, a number of toxicants relative to combustible cigarette smoke. In addition, electronically heating shisha further reduces toxicant levels, and many toxicants are absent in OOKA electronic waterpipe aerosol. These findings have important implications concerning toxicant exposure among waterpipe users, and for understanding how to potentially reduce health risks associated with waterpipe use. En ligne : https://doi.org/10.21203/rs.3.rs-4637991/v1 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10498 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length Type de document : document électronique Auteurs : Chloe Matheson, Auteur ; Tijana Simovic, Auteur ; Allison Heefner, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Angiogenesis, ISSN 1573-7209 num. 27 Importance : p. 229-243 Présentation : ill., graph.; tab. Langues : Anglais (eng) Catégories : [DIVERS] géographie:Amérique:Amérique du Nord:Etats-Unis
[DIVERS] personne:par âge:jeune
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étude
[TABAC] tabagisme:risque:risque cardiovasculaireIndex. décimale : TA 3.2.2.5 Pathologies cardiovasculaires Résumé : Background
Electronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are known to cause vascular dysfunction, one of the earliest indicators of cardiovascular disease (CVD) development. However, little is known about the effect of regular e-cigarette use on vascular function. The purpose of this study was to investigate the impact of regular e-cigarette use on vascular function and cardiovascular health in young, healthy adults.
Methods
Twenty-one regular users of e-cigarettes (ECU) and twenty-one demographically matched non-users (NU) completed this study. Vascular health was assessed in the cutaneous microcirculation through different reactivity tests to evaluate overall functionality, endothelium-dependent vasodilation (EDD), and endothelium-independent vasodilation (EID). Macrovascular function was assessed using flow-mediated dilation (FMD).
Results
Our results suggest that regular users of e-cigarettes present with premature microvascular impairment when compared to non-users. Specifically, they exhibit lower hyperemic (p = 0.003), thermal (p = 0.010), and EDD (p = 0.004) responses. No differences in EID between the groups were identified. We also identified that individuals who use e-cigarettes for longer than 3 years also present with systemic manifestations, as observed by significantly reduced macrovascular (p = 0.002) and microvascular (p ≤ 0.044) function.
Conclusions
Our novel data suggests that young, apparently healthy, regular users of e-cigarettes present with premature vascular dysfunction in the microcirculation when compared to non-users. We have also identified systemic vascular dysfunction affecting both the micro and macrovasculature in those young individuals who used e-cigarettes for longer than 3 years. Taken together, these findings associate regular e-cigarette use with premature vascular dysfunctions and adverse cardiovascular outcomes.En ligne : https://doi.org/10.1007/s10456-023-09903-7 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10536 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Factors influencing JUUL e-cigarette nicotine vapour-induced reward, withdrawal, pharmacokinetics and brain connectivity in rats : sex matters Type de document : document électronique Auteurs : Jude A. Frie, Auteur ; Patrick McCunn, Auteur ; Amr Eed, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Neuropsychopharmacology, ISSN 2948-1570 num. 49 Importance : p. 782-795 Présentation : ill., graph.; tab. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique
[TABAC] tabagisme:aspect psychologique:comportementIndex. décimale : TA 3.2.2.1 Expérimentation Résumé : Though vaping likely represents a safer alternative to smoking, it is not without risks, many of which are not well understood, especially for vulnerable populations. Here we evaluate the sex- and age-dependent effects of JUUL nicotine vapour in rats. Following passive nicotine vapour exposures (from 59 mg/ml JUUL nicotine pods), rats were evaluated for reward-like behaviour, locomotion, and precipitated withdrawal. Pharmacokinetics of nicotine and its metabolites in brain and plasma and the long-term impact of nicotine vapour exposure on functional magnetic resonance imaging-based brain connectivity were assessed. Adult female rats acquired conditioned place preference (CPP) at a high dose (600 s of exposure) of nicotine vapour while female adolescents, as well as male adults and adolescents did not. Adult and adolescent male rats displayed nicotine vapour-induced precipitated withdrawal and hyperlocomotion, while both adult and adolescent female rats did not. Adult females showed higher venous and arterial plasma and brain nicotine and nicotine metabolite concentrations compared to adult males and adolescent females. Adolescent females showed higher brain nicotine concentration compared to adolescent males. Both network-based statistics and between-component group connectivity analyses uncovered reduced connectivity in nicotine-exposed rats, with a significant group by sex interaction observed in both analyses. The short- and long-term effects of nicotine vapour are affected by sex and age, with distinct behavioural, pharmacokinetic, and altered network connectivity outcomes dependent on these variables. En ligne : https://doi.org/10.1038/s41386-023-01773-3 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10590 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Forecasting vaping health risks through neural network model prediction of flavour pyrolysis reactions Type de document : document électronique Auteurs : Akihiro Kishimoto, Auteur ; Dan Wu, Auteur ; Donal F. O’Shea, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Scientific Reports num. 14 Importance : 14 p. Présentation : graph., tab., ill. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac
[TABAC] chimie du tabac:constituant:additif:agent de saveur
[TABAC] tabagisme:effet du tabac:effet neurologiqueMots-clés : e-liquide Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Vaping involves the heating of chemical solutions (e-liquids) to high temperatures prior to lung inhalation. A risk exists that these chemicals undergo thermal decomposition to new chemical
entities, the composition and health implications of which are largely unknown. To address this concern, a graph-convolutional neural network (NN) model was used to predict pyrolysis reactivity
of 180 e-liquid chemical flavours. The output of this supervised machine learning approach was a dataset of probability ranked pyrolysis transformations and their associated 7307 products. To refine this dataset, the molecular weight of each NN predicted product was automatically correlated with experimental mass spectrometry (MS) fragmentation data for each flavour chemical. This blending of deep learning methods with experimental MS data identified 1169 molecular weight matches that prioritized these compounds for further analysis. The average number of discrete matches per flavour between NN predictions and MS fragmentation was 6.4 with 92.8% of flavours having at least one match. Globally harmonized system classifications for NN/MS matches were extracted
from PubChem, revealing that 127 acute toxic, 153 health hazard and 225 irritant classifications were predicted. This approach may reveal the longer-term health risks of vaping in advance of clinical diseases emerging in the general population.En ligne : https://doi.org/10.1038/s41598-024-59619-x Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10289 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Health warning labels on heated tobacco products and their impact on use intentions and risk perceptions : a cross‑sectional study of adult tobacco users in the US and Israel Type de document : document électronique Auteurs : Zongshuan Duan, Auteur ; Hagai Levine, Auteur ; Yael Bar‑Zeev, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Israel Journal of Health Policy Research Importance : 10 p. Présentation : tab.,graph., Langues : Anglais (eng) Catégories : [DIVERS] géographie:Amérique:Amérique du Nord:Etats-Unis
[TABAC] chimie du tabac:tabac non fumé:tabac chauffé
[TABAC] économie du tabac:fabrication du tabac:étiquetage:avertissement sanitaire
[TABAC] étude
[TABAC] prévention:stratégieMots-clés : Israël Index. décimale : TA 9.3.4 Avertissements sanitaires Résumé : Background
Health warning labels (HWLs) represent an evidence-based tobacco control strategy; however, their
application to heated tobacco products (HTPs) and related impacts are understudied. This study examined the impact of HTP HWLs on HTP use intentions and risk perceptions among current tobacco users.
Methods
We analyzed cross-sectional survey data from adults in the US and Israel reporting past-month tobacco use and awareness of HTPs (N = 424). Multivariate analyses examined: (1) sociodemographics in relation to self-reported impact of HTP HWLs (i.e., more concerned about HTP use, reassured, no effect [referent]) among those who noticed HTP HWLs (multinomial regressions); and (2) HWL impacts in relation to HTP use intentions and perceived addictiveness and harm (linear regressions).
Results Among participants who noticed HTP HWLs (n = 372, 87.7%), 27.7% reported HWLs increased their concerns about HTP use, 22.6% were reassured about use, and 49.7% reported no effect. Factors associated with increased concern (vs. no effect) included other tobacco product use (aOR = 2.10, 95% CI 1.21–3.64) and being female (aOR = 1.77, 95% CI 1.03–3.05). Factors associated with being reassured about HTPs use (vs. no effect) included current HTP use (aOR = 2.11, 95% CI 1.11–4.00) and being from Israel (vs. US: aOR = 3.85, 95% CI 1.85–7.69), female (aOR = 1.91, 95% CI 1.07–3.42), and less educated (< college education: aOR = 2.57, 95% CI 1.42–4.63). Reporting that HWLs on HTPs increased concern (β = 0.46, 95% CI 0.03–0.89) and reassured of use (β = 0.94, 95% CI 0.47–1.41) were positively associated with HTP use intentions; no associations with risk perceptions were found.
Conclusions
Findings indicate that most tobacco users noticed HWLs on HTPs, but the majority reported no effect or being reassured of using HTPs, effects that were magnified for specific subgroups. Both increased concern and reassurance correlated with greater use intentions. Additional research should evaluate HTP HWL impacts and ensure effectiveness in communicating risks and discouraging use.En ligne : https://doi.org/10.1186/s13584-023-00582-9 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10262 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Immunology in COPD and the use of combustible cigarettes and heated tobacco products Type de document : document électronique Auteurs : Justyna Błach, Auteur ; Mateusz Siedliński, Auteur ; Wojciech Sydor, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : European Journal of Medical Research Importance : 10 p. Présentation : ill. Langues : Anglais (eng) Catégories : [TABAC] tabagisme:pathologie:pathologie respiratoire:broncho-pneumopathie chronique obstructive Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Chronic obstructive pulmonary disease (COPD) is one of the most common chronic respiratory diseases, characterised by high morbidity and mortality. COPD is characterised by a progressive decline of lung function caused by chronic inflammatory reactions in the lung tissue due to continual exposure to harmful molecules by inhalation. As prevention plays a very important role in COPD, quitting smoking is the most important factor in reducing the decline in lung function. Unfortunately, many people are unable to break their nicotine addiction. This paper summarises current knowledge about combustible cigarettes (CSs) and alternative tobacco products such as heated tobacco products (HTPs) in COPD. The paper focuses on the immunological aspects of COPD and the influence of tobacco products on lung tissue immunology. There are differences in research results between HTPs and CSs in favour of HTPs. More long-term studies are needed to look at the effects of HTPs, especially in COPD. However, there is no doubt that it would be best for patients to give up their nicotine addiction completely. En ligne : https://doi.org/10.1186/s40001-023-01374-2 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10260 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Marketing claims, promotional strategies, and product information on Malaysian e-cigarette retailer websites-a content analysis Type de document : document électronique Auteurs : Sameeha Misriya Shroff, Auteur ; Chandrashekhar T Sreeramareddy, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Substance Abuse Treatment, Prevention, and Policy Importance : 9 p. Présentation : tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] économie du tabac:marketing
[TABAC] législationMots-clés : e-commerce - Malaisie Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Background
Marketing and sales of e-cigarettes are unregulated in Malaysia. We analyzed content displayed on e-cigarette retailer websites to identify marketing claims, promotional strategies, and product details in the year 2022.
Methods
We analyzed 30 Malaysia-based retailer websites using a mixed methods approach. Data were extracted as the frequency of occurrences of marketing claims, presence of regulatory information, product types, and flavors of e-juice as per a predefined codebook based on published literature. We also extracted textual details published on the websites about marketing claims, and slogans.
Results
Most retailer websites provided contact information and physical store addresses (83%) but only half had ‘click through’ age verification (57%) that seldom needed any identification proof for age (3%). Marketing claims were related to health (47%), smoking cessation (37%), and modernity/trend (37%) and none had health warnings.
Promotional strategies were discounts (80%). starter kits (57%) and email subscriptions (53%). Product types displayed were rechargeable (97%) and disposable (87%) devices and e-liquids (90%) of an array of flavors (> 100). Nicotine presence, its concentration, and “nicotine is an addictive chemical” were displayed in 93%, 53%, and 23% of websites respectively.
Conclusion
Surveillance of content displayed online on e-cigarette retailer websites and regulation of online marketing and sales should be implemented by the Ministry of Health, Malaysia. Such measures are needed to prevent access to, and initiation of e-cigarette use among the youth and adults who do not smoke.En ligne : https://doi.org/10.1186/s13011-024-00592-z Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10229 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Physical and chemical characterizations of a reference e‑cigarette used in animal testing Type de document : document électronique Auteurs : Sébastien Soulet, Auteur ; Léa Constant, Auteur ; Vanille Quinty, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports Importance : 10 p. Présentation : graph. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étudeMots-clés : Expérimentation animale :-(
caractéristiques physiques... du produitIndex. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : A minimal necessary condition for preclinical studies to contribute to risk assessments of e-cigarettes (ECs) is the ability to expose laboratory animals to an appropriate dosage of aerosols. In this study, we examined the fulfilment of this essential consistency condition for the ECX-Joyetech E-Vic Mini (ECX),a piece of computerized exposure equipment manufactured by SCIREQ, which has been employed by numerous in vivo testing. We began by calibrating the customary Evic VTC mini device mod and the 4 coils available, reproducing in the laboratory the operation of the ECX in the power-control and temperature-control modes, using puffing parameters recommended by its documentation. We then conducted the following tests for each coil: (1) verifying whether the generated aerosols satisfy an optimal operational regime, free from overheating, as determined by a linear relation between the mass of vaporized e-liquid vs. supplied power and (2) obtaining the mean yields of aldehydes for each of the tested power settings and coils. The results of these tests show that, under the main conditions used in in vivo testing, the ECX equipment fails to comply with these consistency requirements, especially for coils with low subohm resistance, a shortcoming that can be corrected by applying much larger airflows for these coils. Therefore, the outcomes of preclinical studies using the ECX equipment should be examined with great scepticism and subjected to further testing. En ligne : https://doi.org/10.1038/s41598-023-43733-3 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10255 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Risks and benefits of nicotine to aid smoking cessation in pregnancy Type de document : texte imprimé Auteurs : Delia A. Dempsey, Auteur ; Neal L. Benowitz, Auteur Editeur : Springer Nature Année de publication : 2001 Collection : Drug Safety, ISSN 0114-5916 num. 24 Importance : p.277-322 Langues : Anglais (eng) Catégories : [TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:substitution nicotinique
[TABAC] tabagisme:évaluation du tabagisme:test de dépendance à la nicotine
[TABAC] tabagisme:risque:facteur associé:grossesse
[TABAC] tabagisme:tabagisme actif:tabagisme féminin:tabagisme durant la grossesseIndex. décimale : TA 6.7 Facteurs influents (grossesse, adolescence…) Résumé : Cigarette smoking during pregnancy is the single largest modifiable risk for pregnancy-related morbidity and mortality in the US. Addiction to nicotine prevents many pregnant women who wish to quit smoking from doing so. The safety and efficacy of nicotine replacement therapy (NRT) for smoking cessation during pregnancy have not been well studied. En ligne : https://doi.org/10.2165/00002018-200124040-00005 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10394 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : A scoping review of behavioural studies on heated tobacco products Type de document : document électronique Auteurs : Ian M. Fearon, Auteur ; Sarah F. Codery, Auteur ; Martin Fitzpatrick, Auteur Editeur : Springer Nature Année de publication : 2024 Collection : Cureus, ISSN 2168-8184 num. 16(7) Importance : p. 1-37 Présentation : ill. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] chimie du tabac:tabac non fumé:tabac chauffé
[TABAC] étude
[TABAC] sevrage tabagique
[TABAC] tabagisme:aspect psychologique:comportement
[TABAC] tabagisme:risqueIndex. décimale : TA 4.1 Habitudes tabagiques Résumé : Heated tobacco products (HTPs) are electronic devices that heat tobacco sticks to temperatures much lower than those which cause pyrolysis and combustion in cigarettes. While this electrical heating causes the formation of an inhalable aerosol which contains nicotine, the aerosol from HTPs contains significantly fewer and lower levels of the harmful and potentially harmful chemicals found in cigarette smoke. As a result, HTP use potentially conveys reduced risks to health compared to cigarette smoking. While this relative reduction in individual health risk is becoming clearer, what is less certain is the impact of HTPs on overall population‑level health, taking into account both the potential positive impact on adult smokers who completely switch to using HTPs and any unintended impacts such as use by tobacco non‑users and particularly by youth. The aim of this scoping review was to collate and evaluate the published scientific evidence to date, with a cut‑off of 1 January 2024, investigating the impact of HTPs on population‑level health. This evaluation suggests that HTP use is almost exclusively observed among those with a history of cigarette smoking, and there is a growing body of evidence for the ability of HTPs to provide support for adult smokers to transition away from cigarette smoking, in the absence of any significant “gateway” into tobacco use initiation. Many studies have reported a significant degree of dual use of cigarettes and HTPs, and efforts to assess the reasons for such patterns of use, whether these provide overall exposure reductions, and whether dual use acts as a bridge towards a complete transition away from cigarette smoking, requires further investigation. In addition, correction of the widespread and increasing misperceptions of HTPs among adult smokers is recommended to promote HTP uptake as a potentially less harmful alternative to smoking in this population. En ligne : https://doi.org/10.7759/cureus.65773 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10497 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Smoking, tobacco dependence, and neurometabolites in the dorsal anterior cingulate cortex Type de document : document électronique Auteurs : Joseph O'Neill, Auteur ; Maylen Perez Diaz, Auteur ; Jeffry R. Alger, Auteur ; Jean-Baptiste Pochon, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Molecular Psychiatry Importance : 10 p. Présentation : tab., ill., graph. Langues : Anglais (eng) Catégories : [DIVERS] anatomie:corps humain:système nerveux:cerveau
[TABAC] tabagisme:effet du tabac:effet neurologiqueIndex. décimale : TA 3.2.2.6 Effets métaboliques et biologiques Résumé : Cigarette smoking has a major impact on global health and morbidity, and positron emission tomographic research has provided evidence for reduced inflammation in the human brain associated with cigarette smoking. Given the consequences of inflammatory dysfunction for health, the question of whether cigarette smoking affects neuroinflammation warrants further investigation.
The goal of this project therefore was to validate and extend evidence of hypoinflammation related to smoking, and to examine the potential contribution of inflammation to clinical features of smoking. Using magnetic resonance spectroscopy, we measured levels of neurometabolites that are putative neuroinflammatory markers. N-acetyl compounds (N-acetylaspartate + Nacetylaspartylglutamate), glutamate, creatine, choline-compounds (phosphocholine + glycerophosphocholine), and myo-inositol, have all been linked to neuroinflammation, but they have not been examined as such with respect to smoking. We tested whether people who smoke cigarettes have brain levels of these metabolites consistent with decreased neuroinflammation, and whether clinical features of smoking are associated with levels of these metabolites. The dorsal anterior cingulate cortex was chosen as the region-of-interest because of previous evidence linking it to smoking and related states.
Fifty-four adults who smoked daily maintained overnight smoking abstinence before testing and were compared with 37 nonsmoking participants. Among the smoking participants, we tested for associations of metabolite levels with tobacco dependence, smoking history, craving, and withdrawal. Levels of N-acetyl compounds and glutamate were higher, whereas levels of creatine and choline compounds were lower in the smoking group as compared with the nonsmoking group. In the smoking group, glutamate and creatine levels correlated negatively with tobacco dependence, and creatine correlated negatively with lifetime smoking, but none of the metabolite levels correlated with craving or withdrawal. The findings indicate a link between smoking and a hypoinflammatory state in the brain, specifically in the dorsal anterior cingulate cortex. Smoking may thereby increase vulnerability to infection and brain injury.
En ligne : https://doi.org/10.1038/s41380-023-02247-0 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10259 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : The associations of parental smoking, quitting and habitus with teenager e‑cigarette, smoking, alcohol and other drug use in GUI Cohort ’98 Type de document : document électronique Auteurs : Salome Sunday, Auteur ; Luke Clancy, Auteur ; Joan Hanafin, Auteur Editeur : Springer Nature Année de publication : 2023 Collection : Scientific Reports num. 13(20105) Importance : 11 p. Présentation : graph.; tab. Langues : Anglais (eng) Catégories : [DIVERS] personne:famille:adolescent
[DIVERS] personne:famille:enfant
[DIVERS] personne:par âge:jeune
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] tabagisme:aspect psychologique:comportement
[TABAC] tabagisme:risque:facteur associé:alcool
[TABAC] tabagisme:risque:facteur associé:drogue
[TABAC] tabagisme:tabagisme actif:tabagisme parentalIndex. décimale : TA 2.4.1 Enfants et jeunes Résumé : We analyse parental smoking and cessation (quitting) associations with teenager e-cigarette, alcohol, tobacco smoking and other drug use, and explore parental smoking as a mechanism for social reproduction. We use data from Waves 1–3 of Growing Up in Ireland (Cohort ’98). Our analytic sample consisted of n = 6,039 participants reporting in all 3 Waves. Data were collected in Waves 1 and 2 when the children were 9 and 13 years old and in Wave 3 at age 17/18 years. Generalized Estimating Equations (GEE) models were used to analyse teenage substance use at Wave 3. Parental smoking was associated with significantly increased risk of all teenage substance use, adjusted odds ratios were aOR2.13 (ever e-cigarette use); aOR1.92 (ever alcohol use); aOR1.88 (current alcohol use); aOR1.90 (ever use of other drugs); aOR2.10 (ever-smoking); and aOR1.91 (current smoking). Primary caregiver smoking cessation (quitting) was associated with a lower risk for teenager current smoking aOR0.62, ever e-cigarette use aOR 0.65 and other drug use aOR 0.57. Primary caregiver smoking behaviour had greater associations than secondary, and age13 exposure more than age 9. Habitus seems to play a role and wealth was protective for teenage smoking. The findings suggest that prevention interventions should target both caregivers and their children. En ligne : https://doi.org/10.1038/s41598-023-47061-4 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10606 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
