| Titre : |
The influence of nicotine on granulocytic differentiation : inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase : 9 release |
| Type de document : |
texte imprimé |
| Auteurs : |
Minqi Xu, Auteur |
| Editeur : |
BioMed Central |
| Année de publication : |
15/04/2008 |
| Collection : |
BMC Cell Biology num. 9 (19) |
| Importance : |
49 p. |
| Note générale : |
Dans la bibliothèque virtuelle (articles scientifiques) |
| Catégories : |
[TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] tabagisme:effet du tabac
|
| Index. décimale : |
TA 3.2.2.6 Effets métaboliques et biologiques |
| Résumé : |
Background: Neutrophils leave the bone marrow as terminally differentiated cells, yet little is known of the influence of nicotine or other tobacco smoke components on neutrophil differentiation. Therefore, promyelocytic HL-60 cells were differentiated into neutrophils using dimethylsulfoxide in the presence and absence of nicotine (3-(1-methyl-2-pyrrolidinyl) pyridine). Differentiation was evaluated over 5 days by monitoring terminal differentiation markers (CD11b expression and formazan deposition) cell viability, growth phase, kinetics, and apoptosis assessing cellular morphology and ultrastructure and conformational changes to major cellular components. Key neutrophil effector functions (oxidative burst, bacterial killing, matrix metalloproteinase release) were also examined. Conclusions: These findings may partially explain the known increase in susceptibility to bacterial infection and neutrophil-associated destructive inflammatory diseases in individuals chronically exposed to nicotine. |
| En ligne : |
https://doi.org/10.1186%2F1471-2121-9-19 |
| Format de la ressource électronique : |
Article en ligne |
| Permalink : |
https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=1472 |
The influence of nicotine on granulocytic differentiation (15/04/2008)
