| Titre : |
Real-world efficacy of prescription and over-the-counter nicotine replacement therapy |
| Type de document : |
document électronique |
| Auteurs : |
Saul Shiffman, Auteur ; Clyde N. Rolf, Auteur ; Stephen J. Hellebusch, Auteur ; Jane Gorsline, Auteur ; W. Gorodetzky, Auteur ; Yu-Kun Chiang, Auteur ; Debra S. Schleusener, Auteur ; Michael E. Di Marino, Auteur |
| Editeur : |
Society for the study of addiction to alcohol and other drugs |
| Année de publication : |
2001 |
| Collection : |
Addiction num. 97 |
| Importance : |
p.505-516 |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:chewing-gum
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:patch à la nicotine
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:substitution nicotinique
|
| Index. décimale : |
TA 6.2.3.1 Substitution nicotinique |
| Résumé : |
Aims To assess smoking cessation rates achieved with nicotine gum and patch in simulated over-the-counter (OTC) and actual prescription (Rx) settings.
Design Separate open-label studies with gum and patch in OTC and Rx settings.
Participants There were multiple samples: OTC gum: 2981 smokers; OTC patch: 2367; Rx gum: 324; Rx patch: 669.
Interventions All smokers received active nicotine replacement. In the OTC setting, smokers self-selected doses of nicotine gum (2 or 4mg Nicorette®) or patch (21, 14 or 7mg NicoDerm® CQ). No intervention was provided. In the Rx setting, smokers were prescribed gum or patch by their physician.
Measurements Biochemically verified continuous smoking abstinence was assessed at 6 weeks (28-day abstinence) and 6 months.
Findings OTC success rates were consistently higher than Rx rates: differences were significant at 6 weeks for both patch [OR = 1.45 (1.05–1.98)] and gum [OR = 2.92 (1.58–5.40)], and remained significant at 6 months for patch [OR = 3.63; (1.74–7.61)] but not gum [OR = 1.37; (0.73–2.58)]. Among OTC gum users, 16.1% were abstinent at 6 weeks and 8.4% at 6 months. For Rx gum users, abstinence rates were 7.7% at 6 weeks and 7.7% at 6 months. With OTC patch, 19.0% were abstinent at 6 weeks and 9.2% at 6 months. With Rx patch, abstinence rates were 16.0% at 6 weeks and 3.0% at 6 months.
Conclusions Smoking cessation rates achieved with nicotine gum and patch under OTC conditions were as good as those under real-world prescribing conditions.
|
| En ligne : |
https://doi.org/10.1046/j.1360-0443.2002.00141.x |
| Format de la ressource électronique : |
Article en ligne |
| Permalink : |
https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10342 |
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