Effect of low-dose thephylline plus beclometasone on lung function in smokers with asthma / M. Spears (2009)  

Public Titre : Effect of low-dose thephylline plus beclometasone on lung function in smokers with asthma : a pilot stydy Type de document : texte imprimé Auteurs : M. Spears, Auteur ; I. Donnelly, Auteur ; M. Brannigan, Auteur ; K. Ito, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2009 Collection : European Respiratory Journal num. 33 suppl. Importance : p. 1010-1017 Présentation : tab., graph. Langues : Anglais (eng) Catégories : [PROMOSAN] asthme:traitement de l'asthme [TABAC] étude [TABAC] tabagisme:pathologie:pathologie respiratoire:asthme Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Smoking is common in asthma and is associated with worse asthma control and a reduced therapeutic response to corticosteroids. The present authors hypothesised that treating smokers with asthma with low-dose theophylline added to inhaled corticosteroids would enhance steroid sensitivity and thereby improve lung function and symptoms. In a double-blind, parallel group exploratory trial, 68 asthmatic smokers were randomised to one of three treatments for 4 weeks: inhaled beclometasone (200 microg day(-1)), theophylline (400 mg day(-1)) or both treatments combined. Outcome measures included change in lung function and Asthma Control Questionnaire (ACQ) scores. At 4 weeks, theophylline added to inhaled beclometasone produced an improvement in peak expiratory flow (39.9 L min(-1), 95% confidence intervals (CI) 10.9-68.8) and ACQ score (-0.47, 95% CI -0.91- -0.04) and a borderline improvement in pre-bronchodilator forced expiratory volume in one second (mean difference 165 mL, 95% CI -13-342) relative to inhaled corticosteroid alone. Theophylline alone improved the ACQ score (-0.55, 95% CI -0.99- -0.11), but not lung function. In the present pilot study, the combination of low-dose theophylline and inhaled beclometasone produced improvements in both lung function and symptoms in a group of smokers with asthma. Larger trials are required to extend and confirm these findings. En ligne : https://erj.ersjournals.com/content/33/5/1010 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8065

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