Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor / E. Mortaz (2010)  

Public Titre : Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor Type de document : texte imprimé Auteurs : E. Mortaz, Auteur ; I.M. Adcock, Auteur ; K. Ito, Auteur ; A.D. Kraneveld, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2010 Collection : European Respiratory Journal num. 36 Importance : p. 1143-1154 Présentation : graph. Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:fumée [TABAC] étude [TABAC] tabagisme:effet du tabac:effet sur l'immunité [TABAC] tabagisme:pathologie:pathologie respiratoire:broncho-pneumopathie chronique obstructive Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Chronic obstructive pulmonary disease (COPD) is a major health problem and cigarette smoke is the main risk factor for the development of COPD. The characteristic changes in airway morphology, inflammatory cell infiltration and mediator expression in COPD may result from direct effects of cigarette smoke on airway cells. Toll-like receptors (TLRs) are key elements in pathogen recognition by the host immune system. Although TLRs have been intensely studied in innate immunity and infection, their critical role in noninfectious challenges has only recently emerged. Here we investigate whether cigarette smoke induces TLR9 signalling in human neutrophils. Human neutrophils were isolated from buffy coat and exposed to cigarette smoke extract. The production of CXC chemokine ligand (CXCL)8 was measured as a functional readout and the role of TLR9 signalling was investigated. Cigarette smoke extract induced CXCL8 release via TLR9 activation in neutrophils, which was confirmed in TLR9 stably transfected human embryonic kidney 293 cells. Moreover, cigarette smoke extract upregulated the expression of TLR9 and the upregulated expression was suppressed by N-acetylcysteine. TLR9 mediates cigarette smoke-induced release of CXCL8 and this may contribute to the accumulation of neutrophils and inflammation within the airways of smokers. En ligne : https://erj.ersjournals.com/content/36/5/1143 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8071

Exemplaires (1)

Code-barres	Cote	Support	Localisation	Section	Disponibilité
TA 005622	TA 3.2.2.4 MOR C	Article/Périodique	Bibliothèque FARES	Tabac	Consultation sur place Exclu du prêt

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Effect of low-dose thephylline plus beclometasone on lung function in smokers with asthma / M. Spears (2009)  

Public Titre : Effect of low-dose thephylline plus beclometasone on lung function in smokers with asthma : a pilot stydy Type de document : texte imprimé Auteurs : M. Spears, Auteur ; I. Donnelly, Auteur ; M. Brannigan, Auteur ; K. Ito, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2009 Collection : European Respiratory Journal num. 33 suppl. Importance : p. 1010-1017 Présentation : tab., graph. Langues : Anglais (eng) Catégories : [PROMOSAN] asthme:traitement de l'asthme [TABAC] étude [TABAC] tabagisme:pathologie:pathologie respiratoire:asthme Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Smoking is common in asthma and is associated with worse asthma control and a reduced therapeutic response to corticosteroids. The present authors hypothesised that treating smokers with asthma with low-dose theophylline added to inhaled corticosteroids would enhance steroid sensitivity and thereby improve lung function and symptoms. In a double-blind, parallel group exploratory trial, 68 asthmatic smokers were randomised to one of three treatments for 4 weeks: inhaled beclometasone (200 microg day(-1)), theophylline (400 mg day(-1)) or both treatments combined. Outcome measures included change in lung function and Asthma Control Questionnaire (ACQ) scores. At 4 weeks, theophylline added to inhaled beclometasone produced an improvement in peak expiratory flow (39.9 L min(-1), 95% confidence intervals (CI) 10.9-68.8) and ACQ score (-0.47, 95% CI -0.91- -0.04) and a borderline improvement in pre-bronchodilator forced expiratory volume in one second (mean difference 165 mL, 95% CI -13-342) relative to inhaled corticosteroid alone. Theophylline alone improved the ACQ score (-0.55, 95% CI -0.99- -0.11), but not lung function. In the present pilot study, the combination of low-dose theophylline and inhaled beclometasone produced improvements in both lung function and symptoms in a group of smokers with asthma. Larger trials are required to extend and confirm these findings. En ligne : https://erj.ersjournals.com/content/33/5/1010 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8065

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