Systemic sensitivity to corticosteroids in smokers with asthma / E. Livingston (2007)  

Public Titre : Systemic sensitivity to corticosteroids in smokers with asthma Type de document : texte imprimé Auteurs : E. Livingston, Auteur ; R. Chaudhuri, Auteur ; A.D. McMahon, Auteur ; T. Fraser, Auteur Editeur : European Respiratory Society (ERS) Année de publication : 2007 Collection : European Respiratory Journal num. 29 Importance : p. 64-70 Langues : Anglais (eng) Catégories : [PROMOSAN] allergie:traitement de l'allergie:corticoïde [TABAC] étude [TABAC] tabagisme:pathologie:pathologie respiratoire:asthme Index. décimale : TA 3.2.2.2.2 Interactions avec des médicaments Résumé : Cigarette smokers with asthma are insensitive to the therapeutic effects of corticosteroids. It is not known whether this insensitivity to corticosteroids in smokers affects tissue sites beyond the airways. A total of 75 asthmatic subjects (39 smokers) and 78 healthy controls (30 smokers) were recruited to an observational study. The cutaneous and peripheral blood lymphocyte responses to corticosteroids were measured. The cutaneous vasoconstrictor response to topical beclometasone was measured by applying different concentrations of beclometasone solutions to the skin in a random double-blind manner. The degree of blanching at each concentration was graded after 18 h. The sensitivity of peripheral blood lymphocytes to corticosteroids was assessed by measuring the suppressive effect of dexamethasone on lymphocyte proliferation stimulated by phytohaemagglutinin (PHA). Total mean±sd cutaneous vasoconstrictor response score to beclometasone was reduced in smokers with asthma to 5.39±3.58 versus 7.26±3.05 in never-smokers with asthma; and in all smokers to 6.47±3.33 versus 7.86±2.81 in all never-smokers. The sensitivity to corticosteroids of lymphocytes stimulated by PHA was similar between groups. In conclusion, smokers with asthma have an impaired cutaneous vasoconstrictor response to topical corticosteroids compared with never-smokers with asthma. This finding suggests that the insensitivity to corticosteroids in smokers with asthma affects tissue sites other than the airways. En ligne : https://erj.ersjournals.com/content/29/1/64 Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=8067

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Treating patients with respiratory disease who smoke / Georgina Braganza (2008)  

Public Titre : Treating patients with respiratory disease who smoke Type de document : document électronique Auteurs : Georgina Braganza, Auteur ; R. Chaudhuri, Auteur ; Neil C. Thomson, Auteur Editeur : Sage publications Année de publication : 2008 Collection : Therapeutic Advances in Respiratory Disease, ISSN 1753-4666 num. vol.2 n°2 Importance : p.95-107 Langues : Anglais (eng) Catégories : [TUBER] traitement:traitement curatif [TABAC] étude:statistique:prévalence [TABAC] tabagisme:pathologie:pathologie respiratoire:broncho-pneumopathie chronique obstructive [TABAC] tabagisme:tabagisme actif Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : The high prevalence of cigarette smoking in patients with respiratory disease puts them at risk of developing clinically important drug interactions. Cigarette smoking reduces the therapeutic response to certain drugs such as theophyllines through the induction of hepatic cytochrome P450 isoenzymes. Smokers with asthma and patients with COPD have reduced sensitivity to corticosteroids, possibly due to non-eosinophilic airway inflammation, altered glucocorticoid receptor activity or reduced histone deacetylase activity. Although all smokers should be encouraged to stop smoking, there is limited information on the influence of smoking cessation on the therapeutic and anti-inflammatory effects of a number of the drugs used in the treatment of respiratory disease. En ligne : https://doi.org/10.1177/1753465808089697 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10061

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