| Titre : |
An in vitro toxicological assessment of two electronic cigarettes : e-liquid to aerosolisation |
| Type de document : |
document électronique |
| Auteurs : |
E. Bishop, Auteur ; F. Miazzi, Auteur ; S. Bozhilova, Auteur |
| Editeur : |
Elsevier Science Direct |
| Année de publication : |
2024 |
| Collection : |
Current Research in Toxicology num. 6 |
| Importance : |
36 p. |
| Présentation : |
ill., tab., graph. |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:constituant:additif:agent de saveur
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] étude
[TABAC] tabagisme:tabagisme passif
|
| Mots-clés : |
arôme - e-liquide - mécanisme de l'appareil- vapotage hors tabagisme passif - toxicologie - aérosol - test dans le sens de tester les produits, l'appareil |
| Index. décimale : |
TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) |
| Résumé : |
Interest in the toxicological assessment of iterations of e-cigarette devices, e-liquid formulations and flavour use is increasing. Here, we describe a multiple test matrix and
in vitro approach to assess the biological impact of differing e-cigarette activation mechanism (button vs puff-activated) and heating technology (cotton vs ceramic wick). The e-liquids selected for each device contained the same nicotine concentration and flavourings. We tested both e-liquid and aqueous extract of e-liquid aerosol using a high throughput
cytotoxicity and genotoxicity screen. We also conducted whole aerosol assessment both in a reconstituted human airway lung tissue (MucilAir) with associated endpoint assessment
(cytotoxicity, TEER, cilia beat frequency and active area) and an Ames whole aerosol assay with up to 900 consecutive undiluted puffs. Following this testing it is shown that the
biological impact of these devices is similar, taking into consideration the limitations and capturing efficiencies of the different testing matrices. We have contextualised these
responses against previous published reference cigarette data to establish the comparative reduction in response consistent with reduced risk potential of the e-cigarette products
tested in this study as compared to conventional cigarettes. |
| Permalink : |
https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10187 |
|
Ajouter le résultat dans votre panier Affiner la recherche
