| Titre : |
Transfer of folic acid inside the first-trimester gestational sac and the effect of maternal smoking |
| Type de document : |
texte imprimé |
| Auteurs : |
Eric Jauniaux, Auteur ; Jemma Johns, Auteur ; Beatrice Gulbis, Auteur ; Olivera Spasic-Boskovic, Auteur ; Graham J. Burton, Auteur |
| Editeur : |
Paris [France] : Elsevier |
| Année de publication : |
2007 |
| Collection : |
American Journal of Obstetrics and Gynecology num. 197 (58) |
| Note générale : |
Dans la bibliothèque virtuelle (articles scientifiques) |
| Catégories : |
[TABAC] chimie du tabac:fumée:cotinine
[TABAC] tabagisme:risque:facteur associé:grossesse
[TABAC] tabagisme:tabagisme actif:tabagisme parental
|
| Index. décimale : |
TA 3.2.2.7 Grossesse et fœtus |
| Résumé : |
OBJECTIVE: The objective of the study was to investigate the transfer pathways of folic acid inside the first-trimester gestational sac and to evaluate the impact of maternal smoking. STUDY DESIGN: Folate and cotinine levels were evaluated in maternal serum (n = 125) and coelomic fluid (n = 42), and immunostaining was used to identify folate receptors in placental villi, decidual tissue, and secondary yolk sacs from normal pregnancies at 6-12 weeks' gestation. RESULTS: Folate receptors-_were found on the apical surface of syncytiotrophoblast, uterine glandular epithelial cells, and mesothelial layer of the yolk sac. Significantly higher (P<.05) median folate levels were found in maternal serum than in coelomic fluid. The median folate maternal serum and coelomic levels were significantly (P<.0001 and P<.005) lower in smokers, compared with nonsmokers. CONCLUSION: Uterine glands and the secondary yolk sac play key roles in supplying folic acid to the developing fetus before the placental circulations are established, and maternal smoking does not seem to impair directly its transfer mechanism in early pregnancy. |
| En ligne : |
https://doi.org/10.1016/j.ajog.2007.02.009 |
| Format de la ressource électronique : |
Article en ligne |
| Permalink : |
https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=1437 |
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