| Titre : |
Varenicline has antidepressant-like in activity in the forced swim test augments sertraline's effect |
| Type de document : |
texte imprimé |
| Auteurs : |
Hans Rollema, Auteur ; Victor Guanowsky, Auteur ; Yann S. Mineur, Auteur |
| Editeur : |
Elsevier Science Direct |
| Année de publication : |
2009 |
| Collection : |
European Journal of Pharmacology, ISSN 0014-2999 num. Vol 605 |
| Importance : |
p. 114-116 |
| Présentation : |
graph. |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] étude
[TABAC] sevrage tabagique:méthode de sevrage:méthode individuelle:approche pharmacologique:varénicline
|
| Index. décimale : |
TA 6.2.3.1.4 Autres substituts nicotiniques |
| Résumé : |
Varenicline, an alpha4beta2 nicotinic acetylcholine receptor partial agonist developed as a smoking cessation aid, showed antidepressant-like activity in the forced swim test in two mouse strains. In addition, a low varenicline dose significantly enhanced the effects of moderately active doses of the selective serotonin reuptake inhibitor sertraline. These findings are consistent with the notion that reducing alpha4beta2 nicotinic acetylcholine receptor activity either by antagonists or by partial agonists that can partially activate or desensitize acetylcholine receptors is associated with antidepressant-like properties. These data suggest that varenicline may have antidepressant potential and can, when combined, augment antidepressant responses of selective serotonin reuptake inhibitors. |
| Permalink : |
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Varenicline has antidepressant-like in activity in the forced swim test augments sertraline's effect (2009)
