Evaluation of cytotoxic and genotoxic effects in buccal mucosal cells in non-smokers and users of traditional combustible tobacco products and non-combustible alternatives / Antonija Tadin (2024)

Public Titre : Evaluation of cytotoxic and genotoxic effects in buccal mucosal cells in non-smokers and users of traditional combustible tobacco products and non-combustible alternatives Type de document : document électronique Auteurs : Antonija Tadin, Auteur ; Vinka Stazic, Auteur ; Nada Galic, Auteur ; Davor Zeljezic, Auteur Editeur : Bâle [Suisse] : MDPI AG (Molecular Diversity Preservation International) Année de publication : 2024 Collection : Journal of xenobiotics num. 14 Importance : p. 155-165 Présentation : graph., tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette [TABAC] étude [TABAC] tabagisme:effet du tabac:effet bucco-dentaire [TABAC] tabagisme:effet du tabac:toxicité Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Aims/Objectives: The aim of this cross-sectional observational study was to investigate cytogenetic damage to the buccal mucosa in non-smokers and consumers of traditional combustible tobacco products and non-combustible alternatives. Methods: A total of 160 participants were divided into four groups according to the type of product used, including non-smokers, users of conventional combustible tobacco (cigarettes), heated tobacco, and electronic, tobacco-free vapor products (e-cigarettes). Buccal mucosa samples were analyzed using the micronucleus cytome assay to assess cytotoxic and genotoxic damage. Results: E-cigarette users showed significantly higher values for all tested parameters in the micronucleus test compared to non-smokers (p < 0.05). Similarly, users of tobacco heating products showed an increase in all parameters (p < 0.05), with the exception of the number of cells with micronuclei. Conventional cigarette smokers showed a notable increase in the number of binucleated cells and cells with karyorrhexis and karyolysis (p ≤ 0.05). When assessing the differences between users of traditional combustible tobacco products and non-combustible alternatives, these did not appear to be significant, except for e-cigarette users, who had significantly more cells with condensed chromatin (p ≤ 0.001), while users of tobacco heating products had more pyknotic cells (p ≤ 0.001). Conclusion: The results of this study underscore the heightened occurrence of cytotoxic and genotoxic damage in users of both conventional combustible tobacco products and non-combustible alternatives compared to non-smokers, emphasizing the detrimental impact of these products on the oral mucosa. Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10179

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