| Titre : |
Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits |
| Type de document : |
document électronique |
| Auteurs : |
Marcus, R. Orzabal, Auteur ; Emilie, R. Lundr-Young, Auteur ; Josue, I. Ramirez, Auteur |
| Editeur : |
Elsevier |
| Année de publication : |
2019 |
| Collection : |
Translational Research num. 207 |
| Importance : |
p. 70-82 |
| Présentation : |
ill, tab., graph |
| Langues : |
Anglais (eng) |
| Catégories : |
[TABAC] chimie du tabac:constituant:alcaloïde:nicotine
[TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] tabagisme:risque:facteur associé:grossesse:foetus
[TABAC] tabagisme:tabagisme actif:tabagisme féminin:tabagisme durant la grossesse
|
| Index. décimale : |
TA 3.2.2.7 Grossesse et fœtus |
| Résumé : |
Increasing popularity of electronic cigarettes (e-cigs), including among women of reproductive age, is attributed to its perceived safety compared to conventional tobacco. However, there is a major knowledge gap surrounding the effects of e-cig aerosols on pregnancy and fetal development. We aimed to evaluate the effects of vaping e-cigs during gestation on offspring growth and to asses if growth deficits are accompanied by altered maternal and fetal vascular hemodynamics. Sprague ?Dawley dams were assigned to Pair-Fed Control, Pair-Fed Juice, or Juice+Nicotine groups, and then underwent either a prenatal or prenatal+postnatal exposure paradigm in a custom-engineered vaping system. Mass spectrometry identified major aerosolized constituents from e-cig vaping. The Juice+Nicotine group exhibited significantly decreased fetal weight and crown-rump length (#46.56%, and #23.83%, respectively). Pre- and postnatal exposure to Juice+Nicotine resulted in decreased pup weight at postnatal day (PND) 4?10. Crown-rump length was decreased by 24.71% on PND 10. Blood flow in the Juice+Nicotine group was decreased in the maternal uterine and fetal umbilical circuits by 49.50% and 65.33%, respectively. We conclude that chronic exposure to e-cig aerosols containing nicotine during early development can have deleterious health effects on the exposed offspring. Vaping e-cigs containing nicotine during pregnancy lead to a reduction in offspring weight and crown-rump length, associated with a marked decrease in blood flow in both the maternal uterine and fetal umbilical circulation (a strong indicator of growth restriction). Thus, chronic exposure to e-cig aerosols containing nicotine can lead to potentially harmful developmental effects in early life |
| En ligne : |
https://doi.org/10.1016/j.trsl.2019.01.001 |
| Format de la ressource électronique : |
Article en ligne |
| Permalink : |
https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9759 |
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Chronic exposure to e-cig aerosols during early development causes vascular dysfunction and offspring growth deficits (2019)
