| Titre : |
Burden of non-tuberculous mycobacterial pulmonary disease in Germany : a prospective cohort study |
| Type de document : |
document électronique |
| Auteurs : |
Roland Diel, Auteur ; Josephine Jacob, Auteur ; Niklas Lampenius, Auteur |
| Editeur : |
European Respiratory Society (ERS) |
| Année de publication : |
2017 |
| Collection : |
European Respiratory Journal num. 49(4) |
| Importance : |
p. 1602109 |
| Présentation : |
ill. ; graph. ; tab. |
| Langues : |
Anglais (eng) |
| Catégories : |
[DIVERS] géographie:Europe:Europe occidentale:Allemagne
[TUBER] cause:bacille de Koch
[TUBER] étude:épidémiologie
[TUBER] type de tuberculose:tuberculose-maladie:tuberculose pulmonaire
|
| Index. décimale : |
TU 2.6. Autres types de tuberculoses |
| Résumé : |
The objective of this study was to estimate the burden of disease in incident patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD).
A sample of 7 073 357 anonymised persons covered by German public statutory health insurances was used to identify patients with NTM-PD. In total, 125 patients with newly diagnosed NTM-PD in 2010 and 2011 were matched with 1250 control patients by age, sex and Charlson Comorbidity Index, and followed for 39 months.
The incidence rate for NTM-PD was 2.6 per 100000 insured persons (95% CI 2.2–3.1). The mortality rate for patients with NTM-PD and the control group in the observational period was 22.4% and 6%, respectively (p<0.001). Mean direct expenditure per NTM-PD patient was €39 559.60 (95% CI
26 916.49–52 202.71), nearly 4-fold (3.95, 95% CI 3.73–4.19) that for a matched control (€10 006.71, 95% CI 8907.24–11106.17). Hospitalisations were three times higher in the NTM-PD group and accounted for 63% of the total costs. Attributable annual direct costs and indirect work-loss costs in NTM-PD patients were €9093.20 and €1221.05 per control patient, respectively. Only 74% of NTM-PD patients received antibiotics and nearly 12% were prescribed macrolide monotherapy. Although NTM-PD is considered rare, the attributable mortality and financial burden in Germany are
high. Efforts to heighten awareness of appropriate therapy are urgently needed. |
| En ligne : |
https://doi.org/10.1183/13993003.02109-2016 |
| Format de la ressource électronique : |
Article en ligne |
| Permalink : |
https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10911 |
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