Effects of electronic cigarette vaping on cardiac and vascular function, and post‑myocardial infarction remodeling in rats / Wangde Dai (2024)  

Public Titre : Effects of electronic cigarette vaping on cardiac and vascular function, and post‑myocardial infarction remodeling in rats Type de document : document électronique Auteurs : Wangde Dai, Auteur ; Jianru Shi, Auteur ; Prabha Siddarth, Auteur ; Juan Carreno, Auteur Editeur : Springer Science Business Media Année de publication : 2024 Collection : Cardiovascular Toxicology num. 24 :2 Importance : 10 p. Présentation : tab., ill., graph. ISBN/ISSN/EAN : 1559-0259 Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique [TABAC] tabagisme:pathologie:pathologie cardio-vasculaire Mots-clés : expérimentation animale Index. décimale : TA 3.2.2.5 Pathologies cardiovasculaires Résumé : The effect of electronic cigarette (E-cig) vaping on cardiac and vascular function during the healing phase of myocardial infarction (MI), and post-MI remodeling was investigated. Sprague Dawley rats were subjected to left coronary artery ligation to induce MI. One week later, rats were randomized to receive either 12 weeks of exposure to purified air (n = 37) or E-cig vapor (15 mg/ml of nicotine) (n = 32). At 12 weeks, cardiac and vascular function, and post-MI remodeling were assessed. Baseline blood flow in the femoral artery did not differ between groups, but peak reperfusion blood flow was blunted in the E-cig group (1.59 ± 0.15 ml/min) vs. the air group (2.11 ± 0.18 ml/min; p = 0.034). Femoral artery diameter after reperfusion was narrower in the E-cig group (0.54 ± 0.02 mm) compared to the air group (0.60 ± 0.02 mm; p = 0.023). Postmortem left ventricular (LV) volumes were similar in the E-cig (0.69 ± 0.04 ml) and air groups (0.73 ± 0.04 ml; p = NS); and myocardial infarct expansion index did not differ between groups (1.4 ± 0.1 in E-cig group versus 1.3 ± 0.1 in air group; p = NS). LV fractional shortening by echo did not differ between groups at 12 weeks (E-cig at 29 ± 2% and air at 27 ± 1%; p = NS). Exposure to E-cig during the healing phase of MI was associated with altered vascular function with reduced femoral artery blood flow and diameter at reperfusion, but not with worsened LV dilation or worsened cardiac function. En ligne : https://doi.org/10.1007/s12012-024-09835-8 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10194

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Electronic cigarette vaping with nicotine causes Increased thrombogenicity and impaired microvascular function in healthy volunteers / Gustaf Lyytinen (2023)  

Public Titre : Electronic cigarette vaping with nicotine causes Increased thrombogenicity and impaired microvascular function in healthy volunteers : a randomised clinical trial Type de document : document électronique Auteurs : Gustaf Lyytinen, Auteur ; Amelie Brynedal, Auteur ; Erik Anesäter, Auteur Editeur : Springer Science Business Media Année de publication : 2023 Collection : Cardiovascular Toxicology Importance : pp. 255-264 Présentation : graph., tab. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette [TABAC] chimie du tabac:constituant:alcaloïde:nicotine [TABAC] étude:recherche:recherche clinique:essai clinique randomisé [TABAC] tabagisme:pathologie:pathologie cardio-vasculaire:accident vasculaire Index. décimale : TA 1.1.1 Cigarettes (« normales », électroniques, aromatisées,…) Résumé : Electronic cigarette (EC) vaping is increasingly popular, despite growing evidence of adverse health effects. To further evaluate the impact of EC use on vascular health, we investigated the effects of brief EC inhalation on flow-dependent thrombus formation and microcirculation in healthy volunteers. The study was performed with a randomised double-blind crossover design. Twenty-two healthy subjects aged between 18 and 45 years with occasional tobacco use were recruited. Subjects inhaled 30 puffs of EC aerosol with and without nicotine on two occasions separated by a wash-out period of at least 1 week. Blood samples were collected at baseline and at 15 and 60 min following exposure and analysed with the Total-Thrombus-formation analysis system evaluating fibrin-rich thrombus formation and platelet thrombus formation in whole blood under flow. Microvascular function was assessed at baseline and 30 min after exposure by laser speckle contrast imaging and iontophoresis of acetylcholine and sodium nitroprusside (SNP) to evaluate the endothelium-dependent and independent pathways of vasodilation. Compared with nicotine free EC aerosol, exposure to EC aerosol with nicotine significantly increased platelet thrombus formation and fibrin-rich thrombus formation at 15 min (p = 0.017 and p = 0.037, respectively) with normalisation after 60 min. Peak SNP-mediated microvascular perfusion, i.e. endothelium-independent vasodilation, was reduced following EC vaping with nicotine compared with baseline (p = 0.006). Thirty puffs of EC aerosol with nicotine increased platelet and fibrin-dependent thrombus formation and reduced microvascular dilatation capacity. No compelling effects of EC vaping without nicotine were observed, indicating nicotine as the main effector. En ligne : https://doi.org/10.1007/s12012-023-09802-9 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10265

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