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'expérimentation animale' 
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Partager le résultat de cette rechercheCombined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice / David Drummond (2017)
Titre : Combined Effects of in Utero and Adolescent Tobacco Smoke Exposure on Lung Function in C57Bl/6J Mice Type de document : document électronique Auteurs : David Drummond, Auteur ; Mélissa Baravalle - Einaudi, Auteur ; Guillaume Lezmi, Auteur Editeur : National Institute of Environmental Health Sciences Année de publication : 2017 Collection : Environmental health perspectives, ISSN 0091-6765 Importance : 31 p. Présentation : tab., ill. Langues : Français (fre) Catégories : [DIVERS] personne:par âge:jeune
[TABAC] chimie du tabac:fumée
[TABAC] étude
[TABAC] tabagisme:pathologie:pathologie respiratoire
[TABAC] tabagisme:risque:facteur associé:grossesse:foetusMots-clés : expérimentation animale Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : Fetal determinants of airway function, such as in utero exposure to maternal cigarette smoke (CS), may create a predisposition to adult airflow obstruction and chronic obstructive pulmonary disease (COPD) in adulthood. It has been suggested that active smoking in adolescence and preexisting airflow obstruction have synergistic deleterious effects.
Objective:
We used a mouse model to investigate whether there is a synergistic effect of exposure to CS in utero and during adolescence on lung function.
Methods:
Female C57Bl/6J mice were exposed to CS or to filtered room air during pregnancy. Exposure to CS began 2 weeks before mating and continued until delivery. After birth, the pups were not exposed to CS until day 21 (D21). Between D21 and D49, corresponding to “adolescence,” litters were randomized for an additional 4 weeks of exposure to CS. Lung morphometry, lung mechanics, and the expression of genes involved in senescence were evaluated in different subsets of mice on D21 and D49.
Results:
In utero exposure to CS induced significant lung function impairment by D21. CS exposure between D21 and D49 induced significant functional impairment only in mice exposed to CS prenatally. On D49, no difference was observed between subgroups in terms of lung p53, p16, p21, and Bax mRNA levels.
Conclusions:
Our findings suggest that prenatal and adolescent CS exposure have a synergistic effect on lung function in mice. The combined effect did not appear to be a consequence of early pulmonary senescence.
Citation:En ligne : http://dx.doi.org/10.1289/EHP54 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=9623 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Effects of electronic cigarette vaping on cardiac and vascular function, and post‑myocardial infarction remodeling in rats Type de document : document électronique Auteurs : Wangde Dai, Auteur ; Jianru Shi, Auteur ; Prabha Siddarth, Auteur ; Juan Carreno, Auteur Editeur : Springer Science Business Media Année de publication : 2024 Collection : Cardiovascular Toxicology num. 24 :2 Importance : 10 p. Présentation : tab., ill., graph. ISBN/ISSN/EAN : 1559-0259 Langues : Anglais (eng) Catégories : [TABAC] chimie du tabac:tabac fumé:cigarette:cigarette électronique
[TABAC] tabagisme:pathologie:pathologie cardio-vasculaireMots-clés : expérimentation animale Index. décimale : TA 3.2.2.5 Pathologies cardiovasculaires Résumé : The effect of electronic cigarette (E-cig) vaping on cardiac and vascular function during the healing phase of myocardial infarction (MI), and post-MI remodeling was investigated. Sprague Dawley rats were subjected to left coronary artery ligation to induce MI. One week later, rats were randomized to receive either 12 weeks of exposure to purified air (n = 37) or E-cig
vapor (15 mg/ml of nicotine) (n = 32). At 12 weeks, cardiac and vascular function, and post-MI remodeling were assessed. Baseline blood flow in the femoral artery did not differ between groups, but peak reperfusion blood flow was blunted in the E-cig group (1.59 ± 0.15 ml/min) vs. the air group (2.11 ± 0.18 ml/min; p = 0.034). Femoral artery diameter after reperfusion
was narrower in the E-cig group (0.54 ± 0.02 mm) compared to the air group (0.60 ± 0.02 mm; p = 0.023). Postmortem left ventricular (LV) volumes were similar in the E-cig (0.69 ± 0.04 ml) and air groups (0.73 ± 0.04 ml; p = NS); and myocardial infarct expansion index did not differ between groups (1.4 ± 0.1 in E-cig group versus 1.3 ± 0.1 in air group; p = NS). LV fractional shortening by echo did not differ between groups at 12 weeks (E-cig at 29 ± 2% and air at 27 ± 1%; p = NS). Exposure to E-cig during the healing phase of MI was associated with altered vascular function with reduced femoral artery blood flow and diameter at reperfusion, but not with worsened LV dilation or worsened cardiac function.En ligne : https://doi.org/10.1007/s12012-024-09835-8 Format de la ressource électronique : Article en ligne Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10194 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
Titre : Third-hand exposure to e-cigarette vapour induces pulmonary efects in mice Type de document : document électronique Auteurs : Andrew E. Thorpe, Auteur ; Chantal Donovan, Auteur ; Richard Y. Kim, Auteur ; Howard J. Vindin, Auteur ; Razia Zakarya, Auteur Editeur : Bâle [Suisse] : MDPI AG (Molecular Diversity Preservation International) Année de publication : 2023 Collection : Toxics num. 11:749 Importance : 12 p. Présentation : graph., tab., ill. Langues : Anglais (eng) Catégories : [TABAC] CANDIDATS:e-cigarette
[TABAC] chimie du tabac:constituant:alcaloïde:nicotineMots-clés : Expérimentation animale Index. décimale : TA 3.2.2.4 Pathologies respiratoires (sauf 3.2.2.1, 3.2.2.2, 3.2.2.3) Résumé : In the last decade, e-cigarette usage has increased, with an estimated 82 million e-cigarette users globally. This is, in part, due to the common opinion that they are “healthier” than tobacco cigarettes or simply “water vapour”. Third-hand e-vapour exposure is the chemical residue left behind from e-cigarette aerosols, which is of concern due to its invisible nature, especially among young children. However, there is limited information surrounding third-hand e-vapour exposure.
This study aimed to investigate the pulmonary effects of sub-chronic third-hand e-vapour exposure in a murine model. BALB/c mice (4 weeks of age) were exposed to a towel containing nicotine free (0 mg) e-vapour, nicotine (18 mg) e-vapour, or no e-vapour (sham) and replaced daily for 4 weeks. At the endpoint, lung function was assessed, and bronchoalveolar lavage fluid and lungs were collected to measure inflammation and fibrosis. Mice exposed to third-hand e-vapour without nicotine had alveolar enlargement compared to sham exposed controls. Mice exposed to third-hand e-vapour with nicotine had reduced bronchial responsiveness to provocation, increased epithelial thickening in large airways, increased epithelial layers in small airways, alveolar enlargement, and increased small airway collagen deposition, compared to sham exposed controls. In conclusion, our study shows that third-hand e-vapour exposure, particularly in the presence of nicotine, negatively affects the lung health of mice and highlights the need for greater public awareness surrounding the dangers of third-hand exposure to e-cigarette vapour.
Permalink : https://biblio.fares.be/opac_css/index.php?lvl=notice_display&id=10217 Aucun avis, veuillez vous identifier pour ajouter le vôtre !
